ReviewCurrent opinion in neurobiology2017
Mechanisms of input and output synaptic specificity: finding partners, building synapses, and fine-tuning communication.
Review in Current opinion in neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Molecular logic for cellular specializations that initiate the auditory parallel processing pathways.Nature communications · 2025Article
- Molecular logic for cellular specializations that initiate the auditory parallel processing pathways.bioRxiv : the preprint server for biology · 2024Article
- Combinatorial expression of γ-protocadherins regulates synaptic connectivity in the mouse neocortex.eLife · 2024Article
- LRRTM3 regulates activity-dependent synchronization of synapse properties in topographically connected hippocampal neural circuits.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Mechanisms Underlying Target Selectivity for Cell Types and Subcellular Domains in Developing Neocortical Circuits.Frontiers in neural circuits · 2021Review
- Circuit-Specific Plasticity of Callosal Inputs Underlies Cortical Takeover.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- A muscle-epidermis-glia signaling axis sustains synaptic specificity during allometric growth ineLife · 2020Article
- Understanding the Molecular and Cell Biological Mechanisms of Electrical Synapse Formation.Frontiers in neuroanatomy · 2020Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
For most neurons to function properly, they need to develop synaptic specificity. This requires finding specific partner neurons, building the correct types of synapses, and fine-tuning these synapses in response to neural activity. Synaptic specificity is common at both a neuron's input and output synapses, whereby unique synapses are built depending on the partnering neuron. Neuroscientists have long appreciated the remarkable specificity of neural circuits but identifying molecular mechanisms mediating synaptic specificity has only recently accelerated. Here, we focus on recent progress in understanding input and output synaptic specificity in the mammalian brain. We review newly identified circuit examples for both and the latest research identifying molecular mediators including Kirrel3, FGFs, and DGLα. Lastly, we expect the pace of research on input and output specificity to continue to accelerate with the advent of new technologies in genomics, microscopy, and proteomics.
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Registered trials
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