Evidence map›Paper›PMID 28388491›Full record

ReviewCurrent opinion in neurobiology2017

Presynaptic morphogenesis, active zone organization and structural plasticity in Drosophila.

David Van Vactor, Stephan J Sigrist

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Article
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  10. Review
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  12. Dynamic Formation of the Protein-Lipid Pre-fusion Complex.bioRxiv : the preprint server for biology · 2024
    Article
  13. Article
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  17. Glutamatergic Synapse Dysfunction inFrontiers in molecular neuroscience · 2022
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

David Van VactorDepartment of Cell Biology and Program in Neuroscience, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA; Okinawa Institute of Science and Technology, Graduate University, Tancha 1919-1, Onna-son, Okinawa, Japan. Electronic address: davie_vanvactor@hms.harvard.edu.
Stephan J SigristInstitut für Biologie/Genetik and NeuroCure, Freie Universität Berlin, Takustrasse 6, D-14195 Berlin, Germany. Electronic address: stephan.sigrist@fu-berlin.de.

Funding

Regulation of sleep by microRNAsP01NS090994 · NINDS · HARVARD MEDICAL SCHOOL · PI GRIFFITH, LESLIE C · 2016 to 2020
$5.7M
Regulation of Synapse Morphogenesis in DrosophilaR01NS069695 · NINDS · HARVARD MEDICAL SCHOOL · PI VAN VACTOR, DAVID L. · 2010 to 2018
$3.3M
NINDS NIH HHS P01 NS090994NINDS NIH HHS R01 NS069695
6 · The paper itself

Abstract

Effective adaptation of neural circuit function to a changing environment requires many forms of plasticity. Among these, structural plasticity is one of the most durable, and is also an intrinsic part of the developmental logic for the formation and refinement of synaptic connectivity. Structural plasticity of presynaptic sites can involve the addition, remodeling, or removal of pre- and post-synaptic elements. However, this requires coordination of morphogenesis and assembly of the subcellular machinery for neurotransmitter release within the presynaptic neuron, as well as coordination of these events with the postsynaptic cell. While much progress has been made in revealing the cell biological mechanisms of postsynaptic structural plasticity, our understanding of presynaptic mechanisms is less complete.

Indexed as

AnimalsDrosophilaNeuronal PlasticityPresynaptic TerminalsSynaptic Transmission

Identifiers

PMID28388491
PMCPMC5501089

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.