Evidence map›Paper›PMID 28388418›Full record

ArticleCell2017

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.

Katherine B Chiappinelli, Pamela L Strissel, Alexis Desrichard, Huili Li, Christine Henke, Benjamin Akman, Alexander Hein, Neal S Rote, Leslie M Cope, Alexandra Snyder and 11 more

Registry-linked trialAbstract readPublished Erratum
PubMed Publisher
In one paragraph

Article in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04186013 (Efficacy of Atezolizumab Concurrent With Radiotherapy in Patients With Muscle-invasive Bladder cáncer), which is not on this map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04186013 phase2active not recruitingnot on this mapstarted 2019, after this paper: background citation

Efficacy of Atezolizumab Concurrent With Radiotherapy in Patients With Muscle-invasive Bladder cáncer (Study ATEZOBLADDERPRESERVE)

TypeinterventionalSponsorSpanish Oncology Genito-Urinary GroupRan2019 to 2027Enrolled39ConditionsBladder CancerArmsAtezolizumab Injection [Tecentriq], External Beam Radiation Therapy (EBRT)
3 · Its place in the literature

Who cites it

88 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Cohesin mutations and chromatin changes in cancer.International journal of cancer · 2026
    Review
  14. Review
  15. Review
  16. Molecular Mechanisms of Sepsis-Associated Acute Kidney Injury.Journal of the American Society of Nephrology : JASN · 2025
    Review
  17. Article
  18. Article
  19. The Dual Role ofBiology · 2025
    Review
  20. Review

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Katherine B Chiappinelli
Pamela L Strissel
Alexis Desrichard
Huili Li
Christine Henke
Benjamin Akman
Alexander Hein
Neal S Rote
Leslie M Cope
Alexandra Snyder
Vladimir Makarov
Sadna Budhu
Dennis J Slamon
Jedd D Wolchok
Drew M Pardoll
Matthias W Beckmann
Cynthia A Zahnow
Taha Merghoub
Timothy A Chan
Stephen B Baylin
Reiner Strick

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.