Evidence map›Paper›PMID 28387757›Full record

ArticleCell death and differentiation2017

GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer.

Wenjing Xing, Yun Xiao, Xinliang Lu, Hongyan Zhu, Xiangchuan He, Wei Huang, Elsa S Lopez, Jerry Wong, Huanyu Ju, Linlu Tian and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  10. Molecular cancer research : MCR · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Wenjing XingDepartment of Immunology, Harbin Medical University, Harbin 150081, China.
Yun XiaoDepartment of Bioinformatics, College of Bioinformatics, Harbin Medical University, Harbin 150081, China.
Xinliang LuDepartment of Immunology, Harbin Medical University, Harbin 150081, China.
Hongyan ZhuDepartment of Immunology, Harbin Medical University, Harbin 150081, China.
Xiangchuan HeDepartment of Immunology, Harbin Medical University, Harbin 150081, China.
Wei HuangDepartment of Immunology, Harbin Medical University, Harbin 150081, China.
Elsa S LopezLaboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Jerry WongLaboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Huanyu JuDepartment of Immunology, Harbin Medical University, Harbin 150081, China.
Linlu TianDepartment of Immunology, Harbin Medical University, Harbin 150081, China.
Fengmin ZhangImmunity & Infection Key laboratory of Heilongjiang Province, Harbin 150081, China.
Hongwei XuDepartment of Immunology, Harbin Medical University, Harbin 150081, China.
Sheng Dian WangCenter of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Xia LiDepartment of Bioinformatics, College of Bioinformatics, Harbin Medical University, Harbin 150081, China.
Michael KarinLaboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Huan RenDepartment of Immunology, Harbin Medical University, Harbin 150081, China.
Harbin Medical University · CNUniversity of California, San Diego · USEducation Department of Heilongjiang Province · CNChinese Academy of Sciences · CNInstitute of Biophysics · CNShanghai University of Medicine and Health Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation is frequently associated with initiation, progression, and metastasis of colorectal cancer (CRC). Here, we unveil a CRC-specific metastatic programme that is triggered via the transcriptional repressor, GFI1. Using data from a large cohort of clinical samples including inflammatory bowel disease and CRC, and a cellular model of CRC progression mediated by cross-talk between the cancer cell and the inflammatory microenvironment, we identified GFI1 as a gating regulator responsible for a constitutively activated signalling circuit that renders CRC cells competent for metastatic spread. Further analysis of mouse models with metastatic CRC and human clinical specimens reinforced the influence of GFI1 downregulation in promoting CRC metastatic spread. The novel role of GFI1 is uncovered for the first time in a human solid tumour such as CRC. Our results imply that GFI1 is a potential therapeutic target for interfering with inflammation-induced CRC progression and spread.

Indexed as

Gene Expression Regulation, NeoplasticAnimalsCell Line, TumorCell MovementColorectal NeoplasmsDisease ProgressionDNA-Binding ProteinsGene Expression ProfilingHT29 CellsHumansInflammationInflammatory Bowel DiseasesLiver NeoplasmsLymphatic MetastasisMiceMice, NudeAKT1 protein, humanDNA-Binding ProteinsGFI1 protein, humanProto-Oncogene Proteins c-aktPTGER2 protein, humanReceptors, Prostaglandin E, EP2 SubtypeRNA, Small InterferingSTAT3 protein, humanSTAT3 Transcription FactorTranscription FactorsTransforming Growth Factor beta

Identifiers

PMID28387757
PMCPMC5423119
OpenAlexW2605215962

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.