Evidence map›Paper›PMID 28387708›Full record

ArticleInternational journal of molecular sciences2017

The Effect of Low-Dose Proteasome Inhibition on Pre-Existing Atherosclerosis in LDL Receptor-Deficient Mice.

Nicola Wilck, Mandy Fechner, Cristian Dan, Verena Stangl, Karl Stangl, Antje Ludwig

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Ubiquitin System.International journal of molecular sciences · 2018
    Article
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nicola WilckMedizinische Klinik für Kardiologie und Angiologie, Charité-Universitätsmedizin Berlin, Campus Mitte, 10117 Berlin, Germany. nicola.wilck@charite.de.
Mandy FechnerMedizinische Klinik für Kardiologie und Angiologie, Charité-Universitätsmedizin Berlin, Campus Mitte, 10117 Berlin, Germany. m.fechner@medizin-im-gruenen.de.
Cristian DanMedizinische Klinik für Kardiologie und Angiologie, Charité-Universitätsmedizin Berlin, Campus Mitte, 10117 Berlin, Germany. cristian.dan@charite.de.
Verena StanglMedizinische Klinik für Kardiologie und Angiologie, Charité-Universitätsmedizin Berlin, Campus Mitte, 10117 Berlin, Germany. verena.stangl@charite.de.
Karl StanglMedizinische Klinik für Kardiologie und Angiologie, Charité-Universitätsmedizin Berlin, Campus Mitte, 10117 Berlin, Germany. karl.stangl@charite.de.
Antje LudwigMedizinische Klinik für Kardiologie und Angiologie, Charité-Universitätsmedizin Berlin, Campus Mitte, 10117 Berlin, Germany. antje.ludwig@charite.de.
Charité - Universitätsmedizin Berlin · DEGerman Centre for Cardiovascular Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysfunction of the ubiquitin-proteasome system (UPS) has been implicated in atherosclerosis development. However, the nature of UPS dysfunction has been proposed to be specific to certain stages of atherosclerosis development, which has implications for proteasome inhibition as a potential treatment option. Recently, low-dose proteasome inhibition with bortezomib has been shown to attenuate early atherosclerosis in low-density lipoprotein receptor-deficient (LDLR

Indexed as

AnimalsAtherosclerosisBortezomibCholesterolCytokinesDisease Models, AnimalMacrophagesMiceMice, Inbred C57BLProteasome InhibitorsReceptors, LDLBortezomibCholesterolCytokinesProteasome InhibitorsReceptors, LDLatherosclerosisinflammationproteasome inhibition

Identifiers

PMID28387708
PMCPMC5412365
OpenAlexW2604662182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.