Evidence map›Paper›PMID 28387649›Full record

ReviewCancer genomics & proteomics

Monochromosomal Hybrids and Chromosome Transfer: A Functional Approach for Gene Identification.

Raj P Kandpal, Arbans K Sandhu, Gurpreet Kaur, Gursurinder P Kaur, Raghbir S Athwal

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Raj P KandpalDepartment of Basic Medical Sciences, Western University of Health Sciences, Pomona, CA, U.S.A. rathwal@temple.edu rkandpal@westernu.edu.
Arbans K SandhuFels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, U.S.A.
Gurpreet KaurFels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, U.S.A.
Gursurinder P KaurFels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, U.S.A.
Raghbir S AthwalFels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, U.S.A. rathwal@temple.edu rkandpal@westernu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional complementation of cellular defects has been a valuable approach for localizing causative genes to specific chromosomes. The complementation strategy was followed by positional cloning and characterization of genes for their biological relevance. We herein describe strategies used for the construction of monochromosomal hybrids and their applications for cloning and characterization of genes related to cell growth, cell senescence and DNA repair. We have cloned RNaseT2, GluR6 (glutamate ionotropic receptor kainate type subunit 2-GRIK2) and protein tyrosine phosphatase, receptor type K (PTPRK) genes using these strategies.

Indexed as

Gene Transfer TechniquesModels, GeneticAnimalsCell FusionCell LineChromosomes, HumanGluK2 Kainate ReceptorHumansHybrid CellsKainic Acid ReceptorsRibonucleasesTumor Suppressor ProteinsGluK2 Kainate ReceptorKainic Acid ReceptorsRibonucleasesRNASET2 protein, humanTumor Suppressor Proteinscell senescenceChromosome transferfunctional cloningGluR6glutamate ionotropic receptor kainate type subunit 2GRIK-2monochromosomal hybridsprotein tyrosine phosphatasereceptor type K (PTPRK)reviewsenescence associated β-galactosidase

Identifiers

PMID28387649
PMCPMC5369314

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.