Evidence map›Paper›PMID 28387599›Full record

ArticleEpigenetics2017

Novel insights into systemic autoimmune rheumatic diseases using shared molecular signatures and an integrative analysis.

Marie Hudson, Sasha Bernatsky, Ines Colmegna, Maximilien Lora, Tomi Pastinen, Kathleen Klein Oros, Celia M T Greenwood

Abstract read
In one paragraph

Article in Epigenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Methylation of T and B Lymphocytes in Autoimmune Rheumatic Diseases.Clinical reviews in allergy & immunology · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marie Hudsona Lady Davis Research Institute , Montréal , QC , Canada.
Sasha Bernatskyc Department of Medicine , McGill University , Montréal , QC , Canada.
Ines Colmegnac Department of Medicine , McGill University , Montréal , QC , Canada.
Maximilien Lorad The Research Institute of the McGill University Health Centre , Montréal , QC , Canada.
Tomi Pastinene McGill University and Genome Quebec Innovation Centre , McGill University , Montréal , QC , Canada.
Kathleen Klein Orosa Lady Davis Research Institute , Montréal , QC , Canada.
Celia M T Greenwooda Lady Davis Research Institute , Montréal , QC , Canada.

Funding

CIHR EP1-120608
6 · The paper itself

Abstract

We undertook this study to identify DNA methylation signatures of three systemic autoimmune rheumatic diseases (SARDs), namely rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis, compared to healthy controls. Using a careful design to minimize confounding, we restricted our study to subjects with incident disease and performed our analyses on purified CD4

Indexed as

AdultAgedAntigens, CD1Arthritis, RheumatoidAutoimmune DiseasesCD4-Positive T-LymphocytesDNA MethylationFemaleGene Expression RegulationGlycoproteinsHepatocyte Nuclear Factor 4HumansLupus Erythematosus, SystemicMaleMiddle AgedPTEN PhosphohydrolaseAntigens, CD1CD1C protein, humanGlycoproteinsHepatocyte Nuclear Factor 4HNF4A protein, humanPTEN PhosphohydrolasePTEN protein, humanDNA methylationintegrative analysissystemic autoimmune rheumatic diseasestranscriptome

Identifiers

PMID28387599
PMCPMC5501195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.