Evidence map›Paper›PMID 28387584›Full record

ArticleRNA biology2017

Deregulation of the non-coding genome in leukemia.

Susanna Teppo, Merja Heinäniemi, Olli Lohi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Susanna Teppoa Tampere Center for Child Health Research, Faculty of Medicine and Life Sciences , University of Tampere and Tampere University Hospital , Tampere , Finland.ORCID 0000-0003-2569-8030
Merja Heinäniemib Institute of Biomedicine, School of Medicine , University of Eastern Finland , Kuopio , Finland.ORCID 0000-0001-6190-3439
Olli Lohia Tampere Center for Child Health Research, Faculty of Medicine and Life Sciences , University of Tampere and Tampere University Hospital , Tampere , Finland.ORCID 0000-0001-9195-0797
Tampere University Hospital · FIUniversity of Eastern Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methodological advances that allow deeper characterization of non-coding elements in the genome have started to reveal the full spectrum of deregulation in cancer. We generated an inducible cell model to track transcriptional changes after induction of a well-known leukemia-inducing fusion gene, ETV6-RUNX1. Our data revealed widespread transcriptional alterations outside coding elements in the genome. This adds to the growing list of various alterations in the non-coding genome in cancer and pinpoints their role in diseased cellular state.

Indexed as

Gene Expression Regulation, LeukemicGenomeHumansLeukemiaOncogene Proteins, FusionRNA, UntranslatedOncogene Proteins, FusionRNA, UntranslatedeRNAGRO-seqleukemianascent RNAtranscriptional regulation

Identifiers

PMID28387584
PMCPMC5546539
OpenAlexW2605273078

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.