ArticleAnnals of the American Thoracic Society2017
Species-Specific Risk Factors, Treatment Decisions, and Clinical Outcomes for Laboratory Isolates of Less Common Nontuberculous Mycobacteria in Washington State.
Article in Annals of the American Thoracic Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Infectious Diseases Among People Experiencing Homelessness: A Systematic Review of the Literature in the United States and Canada, 2003-2022.Public health reports (Washington, D.C. : 1974)Pooled it
- Nosocomial Mycobacterium lentiflavum colonization and infection cluster at a Japanese tertiary care center: report of an outbreak/pseudo-outbreak investigation.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- First recorded isolation ofRadiology case reports · 2025Article
- Efficacy and treatment outcome of infected patients with pulmonaryJournal of clinical tuberculosis and other mycobacterial diseases · 2024Review
- Attenuated tuberculin skin test responses associated with Mycobacterium intracellulare sputum colonization in an adolescent TB prevalence survey in Western Kenya.Tuberculosis (Edinburgh, Scotland) · 2024Article
- Epidemiology of infection by pulmonary non-tuberculous mycobacteria in French Guiana 2008-2018.PLoS neglected tropical diseases · 2022Observational
- Symptom Burden and Medication Use Among Patients with Nontuberculous Mycobacterial Lung Disease.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2021Article
- Epidemiological risk factors and the geographical distribution of eight Mycobacterium species.BMC infectious diseases · 2021Article
- Nontuberculous Mycobacteria and Heterologous Immunity to Tuberculosis.The Journal of infectious diseases · 2019Review
- Nontuberculous mycobacteria in drinking water systems - the challenges of characterization and risk mitigation.Current opinion in biotechnology · 2019Review
- A rare pulmonary pathology complicated with an unusual condition.Breathe (Sheffield, England) · 2019Article
- Studies of antimicrobial resistance in rare mycobacteria from a nosocomial environment.BMC microbiology · 2019Article
- Recent advances in nontuberculous mycobacterial lung infections.F1000Research · 2019Review
- Observational
- Nontuberculous mycobacterial infection in a tertiary care center in Mexico, 2001-2017.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
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6 authors at 1 institution in 1 country.
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Abstract
rationaleNontuberculous mycobacteria (NTM) are a diverse group of environmental organisms that infrequently cause human disease. Understanding of the epidemiologic and clinical characteristics associated with NTM disease is needed to refine diagnostic and treatment strategies, particularly among the less commonly isolated species.
objectivesTo improve knowledge of geographic variance of NTM species, to correlate detailed clinical information with isolation of specific NTM, and to examine the decision to treat and outcomes for specific NTM.
methodsMycobacterial cultures submitted to the University of Washington mycobacterial laboratory from 1998 to 2011 were examined. We report isolation frequency and demographic information from all samples with clinical variables. We also examined treatment decisions and outcomes in a subset of patients with Mycobacterium abscessus complex, Mycobacterium chelonae, Mycobacterium fortuitum, Mycobacterium gordonae, Mycobacterium kansasii, Mycobacterium lentiflavum, Mycobacterium porcinum, and Mycobacterium xenopi.
resultsCultures of NTM were available from 3,470 patients, 937 of whom had clinical data available. When we compared patients born within or outside Washington State, we found that the mycobacterial species frequency varied. Among 168 patients with one of the studied environmental mycobacteria, 72% had major comorbid conditions. Bronchiectasis was common among patients with pulmonary isolation of any NTM, including those with nonpathogenic M. gordonae. Although mortality was high (37%), few deaths were directly attributable to mycobacterial infection. Among 56 patients who met American Thoracic Society criteria for NTM lung disease, 22 were treated, and 19 of those had M. abscessus complex and M. kansasii. The treatment regimens used tended to follow published guidelines.
conclusionsIsolation of NTM varied by geographic region of origin and location within Washington State. Several clinical risk factors were specific to individual species. Comorbid conditions were common in patients with and without mycobacterial disease. Among patients with one of the studied organisms, there was a high mortality rate more frequently related to comorbid conditions than to mycobacterial disease.
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