Evidence map›Paper›PMID 28387393›Full record

ArticleChemical communications (Cambridge, England)2017

Luciferase-Rose Bengal conjugates for singlet oxygen generation by bioluminescence resonance energy transfer.

Seonghoon Kim, HyeongChan Jo, Mijeong Jeon, Myung-Gyu Choi, Sei Kwang Hahn, Seok-Hyun Yun

Open access · hybridAbstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
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  7. Recent advances in nanoparticle carriers for photodynamic therapy.Quantitative imaging in medicine and surgery · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Seonghoon KimHarvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, USA. syun@hms.harvard.edu and Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, Korea.ORCID http://orcid.org/0000-0002-1145-0336
HyeongChan JoGraduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, Korea.
Mijeong JeonGraduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, Korea.ORCID http://orcid.org/0000-0001-5655-8650
Myung-Gyu ChoiDivision of Gastroenterology, Dept. of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, Catholic University, Korea.ORCID http://orcid.org/0000-0003-4083-5187
Sei Kwang HahnDepartment of Materials Science and Engineering, Pohang University of Science and Technology, Korea.ORCID http://orcid.org/0000-0002-7718-6259
Seok-Hyun YunHarvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, USA. syun@hms.harvard.edu and Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, Korea.ORCID http://orcid.org/0000-0002-8903-5909
Harvard University · USKorea Advanced Institute of Science and Technology · KRPohang University of Science and Technology · KRThe Catholic University of Korea Seoul St. Mary's Hospital · KR

Funding

Bioluminecence-activated photodynamic therapy of breast cancerR01CA192878 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI YUN, SEOK-HYUN ANDY · 2015 to 2019
$2.3M
NCI NIH HHS R01 CA192878
6 · The paper itself

Abstract

Conjugates of Rose Bengal and Renilla luciferase generated singlet oxygen upon binding with coelenterazine via bioluminescence resonance energy transfer (BRET). Since the applications of conventional PDT have been limited to superficial lesions due to the limited light penetration in tissue, BRET activated PDT which does not require external light illumination may overcome the limitations of conventional PDT.

Indexed as

Bioluminescence Resonance Energy Transfer TechniquesAnimalsHumansLuciferasesPhotochemotherapyRenillaRose BengalSinglet OxygenLuciferasesRose BengalSinglet Oxygen

Identifiers

PMID28387393
PMCPMC5489260
OpenAlexW2603756307

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.