SynthesisScientific reports2017
Association between assisted reproductive technology and the risk of autism spectrum disorders in the offspring: a meta-analysis.
Synthesis in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Offspring physiology following the use of IVM, IVF and ICSI: a systematic review and meta-analysis of animal studies.Human reproduction update · 2023Pooled it
- Association of assisted reproductive technology with autism spectrum disorder in the offspring: an updated systematic review and meta-analysis.European journal of pediatrics · 2021Pooled it
- The Risk of Retinopathy of Prematurity in the Infants following Assisted Reproductive Technology: A Meta-Analysis.BioMed research international · 2019Pooled it
- Do the children born after in vitro fertilization or intracytoplasmic sperm injection have poor intellectual performance? A prospective cohort study.BMC pregnancy and childbirth · 2026Article
- Association of maternal endometriosis with autism spectrum disorder in offspring: a retrospective cohort study.BMC pregnancy and childbirth · 2025Article
- Exploring the Association Between Medically Assisted Reproduction and Autism Spectrum Disorder: Clinical Correlations from a Retrospective Cohort.Pediatric reports · 2025Article
- NDD-ECHO: A standardised digital assessment tool to capture early life environmental and inflammatory factors for children with neurodevelopmental disorders.Brain, behavior, & immunity - health · 2025Article
- Low glucose challenge test result as a potential risk factor for delays in early child development: the Japan environment and children's study.Journal of diabetes and metabolic disorders · 2025Article
- Article
- Children born to subfertile couples, how are they doing? Evidence from research.Archives of disease in childhood · 2024Review
- Gross movement counting of fetuses conceived with assisted reproductive technology using a fetal movement acceleration measurement recorder.Scientific reports · 2024Article
- Reproductive genetics and health.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2024Article
- The Long-Term Outcome of Children Conceived Through Assisted Reproductive Technology.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- A nationwide, prospective, cohort study on exogenous oxytocin and delays in early child development: the Japan environment and children's study.European journal of pediatrics · 2023Article
- Long-Term Effects of ART on the Health of the Offspring.International journal of molecular sciences · 2023Review
- Ante-, Peri-, and Neonatal Factors Associated with Autism Spectrum Disorders in Vietnam: A Population-Based Cross-Sectional Survey.Iranian journal of public health · 2023Article
- Preimplantation genetic testing and child health: a national register-based study.Human reproduction (Oxford, England) · 2023Article
- Assisted reproductive technology: Short- and long-term outcomes.Developmental medicine and child neurology · 2023Review
- The Well-Being of Adolescents Conceived Through Medically Assisted Reproduction: A Population-Level and Within-Family Analysis.European journal of population = Revue europeenne de demographie · 2022Article
- Fetal neurosonography and infant neurobehavior following conception by assisted reproductive technology with fresh or frozen embryo transfer.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association between the use of assisted reproductive technology (ART) and autism spectrum disorder (ASD) risk in offspring has been explored in several studies, but the result is still inconclusive. We assessed the risk of ASD in offspring in relation to ART by conducting a meta-analysis. A literature search in PubMed, Embase, and Web of Knowledge databases through April 30, 2016 was conducted to identify all the relevant records. Risk ratios (RRs) and 95% confidence intervals (95%CIs) were computed to analyze the strength of association by using fixed- or random-effect models based on heterogeneity test in total and subgroup analyses. Analysis of the total 11 records (3 cohort studies and 8 case-control studies) revealed that the use of ART is associated with higher percentage of ASD (RR = 1.35, 95% CI: 1.09-1.68, P = 0.007). In addition, subgroup analyses based on study design, study location and study quality were conducted, and some subgroups also showed a statistically significant association. Our study indicated that the use of ART may associated with higher risk of ASD in the offspring. However, further prospective, large, and high-quality studies are still required.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.