ArticleScientific reports2017
Origin and spread of human mitochondrial DNA haplogroup U7.
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27 citing papers in PubMed, 42 citations in OpenAlex.
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Authors and funding
79 authors at 20 institutions in 16 countries.
Hovhannes SahakyanEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Baharak Hooshiar KashaniDipartimento di Biologia e Biotecnologie "L. Spallanzani", Università di Pavia, Pavia 27100, Italy.
Rakesh TamangDepartment of Zoology, University of Calcutta, Kolkata 700 019, India.
Alena KushniarevichEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Amirtharaj FrancisCSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
Marta D CostaFaculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.
Ajai Kumar PathakEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Zaruhi KhachatryanLaboratory of Ethnogenomics, Institute of Molecular Biology of National Academy of Sciences, Yerevan 0014, Armenia.
Indu SharmaHuman Genetics Research Group, Department of Biotechnology, Shri Mata Vaishno Devi University, Katra 182320, India.
Mannis van OvenUtrecht 3523 GN, The Netherlands.
Jüri ParikEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Hrant HovhannisyanLaboratory of Ethnogenomics, Institute of Molecular Biology of National Academy of Sciences, Yerevan 0014, Armenia.
Ene MetspaluEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Erwan PennarunEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Monika KarminEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Erika TammEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Kristiina TambetsEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Ardeshir BahmanimehrLaboratory of Ethnogenomics, Institute of Molecular Biology of National Academy of Sciences, Yerevan 0014, Armenia.
Tuuli ReisbergEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Maere ReidlaEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Alessandro AchilliDipartimento di Biologia e Biotecnologie "L. Spallanzani", Università di Pavia, Pavia 27100, Italy.
Anna OlivieriDipartimento di Biologia e Biotecnologie "L. Spallanzani", Università di Pavia, Pavia 27100, Italy.
Francesca GandiniDipartimento di Biologia e Biotecnologie "L. Spallanzani", Università di Pavia, Pavia 27100, Italy.
Ugo A PeregoDipartimento di Biologia e Biotecnologie "L. Spallanzani", Università di Pavia, Pavia 27100, Italy.
Nadia Al-ZaheryDipartimento di Biologia e Biotecnologie "L. Spallanzani", Università di Pavia, Pavia 27100, Italy.
Massoud HoushmandDepartment of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran 14965/161, Iran.
Mohammad Hossein SanatiDepartment of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran 14965/161, Iran.
Pedro SoaresInstituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Porto 4200-135, Portugal.
Ekta RaiHuman Genetics Research Group, Department of Biotechnology, Shri Mata Vaishno Devi University, Katra 182320, India.
Jelena ŠaracEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Tena ŠarićEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Varun SharmaHuman Genetics Research Group, Department of Biotechnology, Shri Mata Vaishno Devi University, Katra 182320, India.
Luisa PereiraInstituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Porto 4200-135, Portugal.
Veronica FernandesFaculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.
Viktor ČernýDepartment of Anthropology and Human Genetics, Faculty of Science, Charles University, Prague 128-43, Czech Republic.
Shirin FarjadianDepartment of Immunology, Allergy Research Center, Shiraz University of Medical Sciences, Shiraz 71348-45794, Iran.
Deepankar Pratap SinghCSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
Hülya AzakliGenetic Department, Institute of Experimental Medicine, Istanbul University, Istanbul 33326, Turkey.
Duran ÜstekDepartment of Medical Genetics and REMER, Faculty of Medicine, Medipol University, Istanbul, 34810 Turkey.
Natalia Ekomasova TrofimovaEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Ildus KutuevEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Sergei LitvinovEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Marina BermishevaInstitute of Biochemistry and Genetics, Ufa Scientific Center of the Russian Academy of Sciences, Ufa 450054, Russia.
Elza K KhusnutdinovaInstitute of Biochemistry and Genetics, Ufa Scientific Center of the Russian Academy of Sciences, Ufa 450054, Russia.
Niraj RaiCSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
Manvendra SinghCSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
Vijay Kumar SinghCSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
Alla G ReddyCSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
Helle-Viivi TolkEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Svjetlana CvjetanInstitute for Anthropological Research, Zagreb 10000, Croatia.
Lovorka Barac LaucInstitute for Anthropological Research, Zagreb 10000, Croatia.
Pavao RudanInstitute for Anthropological Research, Zagreb 10000, Croatia.
Emmanuel N MichalodimitrakisDepartment of Forensic Sciences and Toxicology, University of Crete, School of Medicine, Heraklion 71110, Greece.
Nicholas P AnagnouLaboratory of Biology, University of Athens, School of Medicine, Athens 115 27, Greece.
Kalliopi I PappaFoundation for Biomedical Research of the Academy of Athens (IIBEAA), Athens 115 27, Greece.
Maria V GolubenkoResearch Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk 634050, Russia.
Vladimir OrekhovVavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119333, Russia.
Svetlana A BorinskayaVavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119333, Russia.
Katrin KaldmaEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Monica A SchauerInstitute of Cellular Biology and Pathology "Nicolae Simionescu", Bucharest PO Box 35-14, Romania.
Maya SimionescuInstitute of Cellular Biology and Pathology "Nicolae Simionescu", Bucharest PO Box 35-14, Romania.
Vladislava GusarKharkiv Specialized Medical Genetic Centre (KSMGC), Kharkiv 61022, Ukraine.
Elena GrechaninaKharkiv Specialized Medical Genetic Centre (KSMGC), Kharkiv 61022, Ukraine.
Periyasamy GovindarajCSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
Mikhail VoevodaInstitute of Internal and Preventive Medicine, SB RAS, Novosibirsk 630089, Russia.
Larissa DambaInstitute of Internal and Preventive Medicine, SB RAS, Novosibirsk 630089, Russia.
Swarkar SharmaHuman Genetics Research Group, Department of Biotechnology, Shri Mata Vaishno Devi University, Katra 182320, India.
Lalji SinghCSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
Ornella SeminoDipartimento di Biologia e Biotecnologie "L. Spallanzani", Università di Pavia, Pavia 27100, Italy.
Doron M BeharEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Levon YepiskoposyanLaboratory of Ethnogenomics, Institute of Molecular Biology of National Academy of Sciences, Yerevan 0014, Armenia.
Martin B RichardsFaculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.
Mait MetspaluEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Toomas KivisildEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Kumarasamy ThangarajCSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
Phillip EndicottMusée de l'Homme, Paris 75116, France.
Gyaneshwer ChaubeyEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Antonio TorroniDipartimento di Biologia e Biotecnologie "L. Spallanzani", Università di Pavia, Pavia 27100, Italy.
Richard VillemsEvolutionary Biology Group, Estonian Biocentre, Tartu 51010, Estonia.
Estonian Biocentre · EECentre for Cellular and Molecular Biology · INUniversity of Pavia · ITUniversity of Tartu · EEShri Mata Vaishno Devi University · INInstitute for Anthropological Research · HRNational Academy of Sciences of Armenia · AMRussian Academy of Sciences · RUNational Institute of Genetic Engineering and Biotechnology · IRRomanian Academy · ROUniversidade do Porto · PTUniversity of Leeds · GBVavilov Institute of General Genetics · RUBiomedical Research Foundation of the Academy of Athens · GRCarmel Medical Center · ILCharles University · CZEstonian Academy of Sciences · EEIPO Porto · PTIstanbul Medipol University · TRIstanbul University · TR
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 thousand years, the comparatively recent coalescence time of the extant variation of haplogroup U7 (~16-19 thousand years ago) suggests that its current distribution is the consequence of more recent dispersal events, despite its wide geographical range across Europe, the Near East and South Asia. Here we report 267 new U7 mitogenomes that - analysed alongside 100 published ones - enable us to discern at least two distinct temporal phases of dispersal, both of which most likely emanated from the Near East. The earlier one began prior to the Holocene (~11.5 thousand years ago) towards South Asia, while the later dispersal took place more recently towards Mediterranean Europe during the Neolithic (~8 thousand years ago). These findings imply that the carriers of haplogroup U7 spread to South Asia and Europe before the suggested Bronze Age expansion of Indo-European languages from the Pontic-Caspian Steppe region.
Indexed as
Evolution, MolecularBayes TheoremDNA, MitochondrialGeographyHaplotypesHumansMutationPhylogenyDNA, Mitochondrial
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