ArticleScientific reports2017
Transgenerational transmission of a stress-coping phenotype programmed by early-life stress in the Japanese quail.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- When Does Stress Build Strength? Linking Stress Physiology to Resilience in the Age of Rapid Environmental Change.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Getting Over It: Maternal Stress and Gut Microbiome Manipulations Do Not Affect Rates of Offspring Habituation During Long Bouts of Stress.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Article
- Life at new extremes: Integrating stress physiology and the bio-exposome in the Anthropocene.Annals of the New York Academy of Sciences · 2025Review
- Neuro Emotional Technique as a Treatment for Separation Anxiety Related to Prenatal Stress: A Case Report.Cureus · 2025Article
- Prenatal Corticosterone Impacts Nestling Condition and Immunity in Eastern Bluebirds.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2025Article
- Molecular responses of chicken embryos to maternal heat stress through DNA methylation and gene expression: a pilot study.Environmental epigenetics · 2025Article
- Article
- HPA flexibility andPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- A conceptual framework for understanding stress-induced physiological and transgenerational effects on population responses to climate change.Evolution letters · 2024Article
- From maternal glucocorticoid and thyroid hormones to epigenetic regulation of offspring gene expression: An experimental study in a wild bird species.Evolutionary applications · 2023Article
- The response to stressors in adulthood depends on the interaction between prenatal exposure to glucocorticoids and environmental context.Scientific reports · 2023Article
- Effects of maternal methionine supplementation on the response of Japanese quail (Coturnix coturnix japonica) chicks to heat stress.Journal of animal science · 2023Article
- The immune-neuroendocrine system, a key aspect of poultry welfare and resilience.Poultry science · 2022Article
- Effect of prenatal ambient temperature on the performance physiological parameters, and oxidative metabolism of Japanese quail (Coturnix coturnix japonica) layers exposed to heat stress during growth.Scientific reports · 2021Article
- Immediate and transgenerational effects of thymol supplementation, inactivated Salmonella and chronic heat stress on representative immune variables of Japanese quail.Scientific reports · 2020Article
- Early-Life Stress Induced Epigenetic Changes of Corticotropin-Releasing Factor Gene in Anorexic Low Body Weight-Selected Chicks.Life (Basel, Switzerland) · 2020Article
- Early-life manipulation of cortisol and its receptor alters stress axis programming and social competence.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Transgenerational epigenetic inheritance in birds.Environmental epigenetics · 2018Review
- Integrating Ecological and Evolutionary Context in the Study of Maternal Stress.Integrative and comparative biology · 2017Article
- Why and how the early-life environment affects development of coping behaviours.Behavioral ecology and sociobiologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
An interesting aspect of developmental programming is the existence of transgenerational effects that influence offspring characteristics and performance later in life. These transgenerational effects have been hypothesized to allow individuals to cope better with predictable environmental fluctuations and thus facilitate adaptation to changing environments. Here, we test for the first time how early-life stress drives developmental programming and transgenerational effects of maternal exposure to early-life stress on several phenotypic traits in their offspring in a functionally relevant context using a fully factorial design. We manipulated pre- and/or post-natal stress in both Japanese quail mothers and offspring and examined the consequences for several stress-related traits in the offspring generation. We show that pre-natal stress experienced by the mother did not simply affect offspring phenotype but resulted in the inheritance of the same stress-coping traits in the offspring across all phenotypic levels that we investigated, shaping neuroendocrine, physiological and behavioural traits. This may serve mothers to better prepare their offspring to cope with later environments where the same stressors are experienced.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.