ArticleScientific reports2017
Characterization and genomic analyses of two newly isolated Morganella phages define distant members among Tevenvirinae and Autographivirinae subfamilies.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Genomic profiling ofMicrobiology spectrum · 2026Article
- Comparative Genomic Analysis of 66 Bacteriophages Infecting Morganella morganii Strains.Current microbiology · 2025Article
- Biological characterization and genomic analysis of a novel bacteriophage, MopsHU1, infecting Morganella psychrotolerans.Archives of virology · 2024Article
- Genomic Analysis of Two Novel Bacteriophages InfectingViruses · 2023Article
- Article
- Characterization of Phage vB_SalM_SPJ41 and the Reduction of Risk of Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Article
- Resistant Genes and Multidrug-Resistant Bacteria in Wastewater: A Study of Their Transfer to the Water Reservoir in the Czech Republic.Life (Basel, Switzerland) · 2022Article
- Evolutionary genomics of APSE: a tailed phage that lysogenically converts the bacterium Hamiltonella defensa into a heritable protective symbiont of aphids.Virology journal · 2021Article
- The interactions of bacteriophage Ace and Shiga toxin-producing Escherichia coli during biocontrol.FEMS microbiology ecology · 2021Article
- Biodiversity of New Lytic Bacteriophages InfectingFrontiers in microbiology · 2021Article
- A Tailspike with Exopolysaccharide Depolymerase Activity from a New Providencia stuartii Phage Makes Multidrug-Resistant Bacteria Susceptible to Serum-Mediated Killing.Applied and environmental microbiology · 2020Article
- Characterization of the Three New Kayviruses and Their Lytic Activity Against Multidrug-ResistantMicroorganisms · 2019Article
- Phages for Phage Therapy: Isolation, Characterization, and Host Range Breadth.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Targeting mechanisms of tailed bacteriophages.Nature reviews. Microbiology · 2018Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morganella morganii is a common but frequent neglected environmental opportunistic pathogen which can cause deadly nosocomial infections. The increased number of multidrug-resistant M. morganii isolates motivates the search for alternative and effective antibacterials. We have isolated two novel obligatorily lytic M. morganii bacteriophages (vB_MmoM_MP1, vB_MmoP_MP2) and characterized them with respect to specificity, morphology, genome organization and phylogenetic relationships. MP1's dsDNA genome consists of 163,095 bp and encodes 271 proteins, exhibiting low DNA (<40%) and protein (<70%) homology to other members of the Tevenvirinae. Its unique property is a >10 kb chromosomal inversion that encompass the baseplate assembly and head outer capsid synthesis genes when compared to other T-even bacteriophages. MP2 has a dsDNA molecule with 39,394 bp and encodes 55 proteins, presenting significant genomic (70%) and proteomic identity (86%) but only to Morganella bacteriophage MmP1. MP1 and MP2 are then novel members of Tevenvirinae and Autographivirinae, respectively, but differ significantly from other tailed bacteriophages of these subfamilies to warrant proposing new genera. Both bacteriophages together could propagate in 23 of 27 M. morganii clinical isolates of different origin and antibiotic resistance profiles, making them suitable for further studies on a development of bacteriophage cocktail for potential therapeutic applications.
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