ArticleScientific reports2017
Elevated emotional contagion in a mouse model of Alzheimer's disease is associated with increased synchronization in the insula and amygdala.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 25 citations in OpenAlex.
- Pupillometry and brain-wide c-Fos mapping uncover multimodal mirror emotional contagion related networks of mice.iScience · 2026Article
- Roles of mediodorsal thalamus in observational fear-related neural activity in mouse anterior cingulate cortex.Molecular brain · 2025Article
- Understanding Others' Distress Through Past Experiences: The Role of Memory Engram Cells in Observational Fear.Advances in neurobiology · 2024Review
- A Brain-To-Brain Mechanism for Social Transmission of Threat Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- New horizons in emotional well-being and brain aging: Potential lessons from cross-species research.International journal of geriatric psychiatry · 2023Article
- Hemispherically lateralized rhythmic oscillations in the cingulate-amygdala circuit drive affective empathy in mice.Neuron · 2023Article
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- Heightened emotion processing as a compensatory mechanism in persons with Alzheimer's disease: Psychological insights from the tri-network model.Frontiers in dementia · 2022Review
- A model of negative emotional contagion between male-female rat dyads: Effects of voluntary exercise on stress-induced behavior and BDNF-TrkB signaling.Physiology & behavior · 2021Article
- Conformity-like behaviour in mice observing the freezing of other mice: a model of empathy.BMC neuroscience · 2020Article
- Selective Peripheral Taste Dysfunction in APP/PS1 Mutant Transgenic Mice.Journal of Alzheimer's disease : JAD · 2020Article
- Resting heart rate variability is negatively associated with mirror neuron and limbic response to emotional faces.Biological psychology · 2019Article
- Effective Diagnosis of Alzheimer's DiseaseFrontiers in genetics · 2019Article
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- Social Fear Learning: from Animal Models to Human Function.Trends in cognitive sciences · 2017Review
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2 authors at 1 institution in 1 country.
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Abstract
Emotional contagion, a primitive form of empathy, is heightened in patients with Alzheimer's disease (AD); however, the mechanism underlying this attribute has not been thoroughly elucidated. In this study, observational fear conditioning was performed to measure emotional contagion levels in a mouse model of AD. Simultaneous recording of local field potentials in the bilateral anterior insula, basolateral amygdala, anterior cingulate cortex, and retrosplenial cortex was also conducted to investigate related brain network changes. Consistent with the results obtained with AD patients, 11-month-old AD model mice exhibited significantly higher freezing levels in observational fear conditioning, indicating elevated emotional contagion compared to age-matched wild-type mice. Furthermore, the left anterior insula and right basolateral amygdala of 11-months-old AD model mice indicated sustained increases in synchronization when they observed the suffering of conspecifics. These changes did not appear in other age groups or wild-type controls. Additionally, the amyloid plaque burden within the anterior insula was significantly correlated with the freezing levels in observational fear conditioning. Taken together, this study reveals increased and sustained network synchrony between the anterior insula and basolateral amygdala, which comprise a salience network in humans, as a potential mechanism for elevated emotional contagion in a mouse model of AD.
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