ArticleScientific reports2017
Assessment of Conjunctival Microvascular Hemodynamics in Stages of Diabetic Microvasculopathy.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- ANGPTL4-dependent metabolic reprogramming fuels RhoA signalling and microvascular dysfunction in diabetes.Acta diabetologica · 2026Article
- Independent Conjunctival and Retinal Microcirculatory Improvements Following OcufolinCurrent eye research · 2026Article
- Conjunctival Venular Hemodynamic Biomarkers in Glaucoma.Translational vision science & technology · 2025Article
- Identifying diabetes from conjunctival images using a novel hierarchical multi-task network.Scientific reports · 2022Article
- Eye Sign is an Alternative for Evaluation of the Microcirculation in Patients with Systemic Sclerosis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Progress of Bulbar Conjunctival Microcirculation Alterations in the Diagnosis of Ocular Diseases.Disease markers · 2022Review
- Article
- Quantification of Blood Flow Velocity in the Human Conjunctival Microvessels Using Deep Learning-Based Stabilization Algorithm.Sensors (Basel, Switzerland) · 2021Article
- Assessment of the conjunctival microcirculation for patients presenting with acute myocardial infarction compared to healthy controls.Scientific reports · 2021Article
- An Analysis of the Areas Occupied by Vessels in the Ocular Surface of Diabetic Patients: An Application of a Nonparametric Tilted Additive Model.International journal of environmental research and public health · 2021Article
- Eye care providers' emerging roles in early detection of diabetes and management of diabetic changes to the ocular surface: a review.BMJ open diabetes research & care · 2020Review
- Detection of Subclinical Diabetic Retinopathy by Fine Structure Analysis of Retinal Images.Journal of ophthalmology · 2019Article
- Inter-visit measurement variability of conjunctival vasculature and circulation in habitual contact lens wearers and non-lens wearers.Eye and vision (London, England) · 2019Article
- Factors Affecting Microvascular Responses in the Bulbar Conjunctiva in Habitual Contact Lens Wearers.Investigative ophthalmology & visual science · 2018Article
- Inter-visit variability of conjunctival microvascular hemodynamic measurements in healthy and diabetic retinopathy subjects.Microvascular research · 2018Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Diabetes impairs the microcirculation and function of various vital tissues throughout the body. The conjunctival microcirculation can be non-invasively imaged and thus enables assessment of microvascular hemodynamics. In this study, alterations in conjunctival microvascular hemodynamics were quantitatively assessed at stages of increasing diabetic microvasculopathy based on diabetic retinopathy (DR). Subjects were categorized into non-diabetic control (C, N = 34), no clinically visible DR (NDR, N = 47), non-proliferative DR (NPDR, N = 45), and proliferative DR (PDR, N = 35). Conjunctival hemodynamic descriptors, namely vessel diameter (D), blood velocity (V), blood flow (Q), wall shear rate (WSR), and wall shear stress (WSS) were measured in arterioles and venules, and compared between DR and C subjects using generalized linear mixed models. In arterioles, V, WSR, and WSS were lower in NDR (P ≤ 0.01). V was lower in NDR than NPDR and PDR subjects (P ≤ 0.02). In venules, D was higher in NDR and NPDR (P ≤ 0.03), while V was lower in PDR (P = 0.04). Venular V and Q were higher in NPDR than PDR subjects (P ≤ 0.04). WSR and WSS were lower in all stages of DR (P ≤ 0.05), suggestive of the potential of WSS as a marker of diabetic microvasculopathy. Quantitative assessment of conjunctival hemodynamics can potentially be useful for evaluation of diabetic microvasculopathy.
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