Evidence map›Paper›PMID 28387222›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017

Presynaptic Dopamine Synthesis Capacity in Schizophrenia and Striatal Blood Flow Change During Antipsychotic Treatment and Medication-Free Conditions.

Daniel Paul Eisenberg, Lisa Yankowitz, Angela M Ianni, Dani Y Rubinstein, Philip D Kohn, Catherine E Hegarty, Michael D Gregory, José A Apud, Karen F Berman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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  5. Review
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  7. Neanderthal-derived genetic variation in living humans relates to schizophrenia diagnosis, to psychotic symptom severity, and to dopamine synthesis.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Daniel Paul EisenbergSection on Integrative Neuroimaging, Clinical &Translational Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Lisa YankowitzSection on Integrative Neuroimaging, Clinical &Translational Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Angela M IanniSection on Integrative Neuroimaging, Clinical &Translational Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Dani Y RubinsteinSection on Integrative Neuroimaging, Clinical &Translational Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-6292-7392
Philip D KohnSection on Integrative Neuroimaging, Clinical &Translational Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Catherine E HegartySection on Integrative Neuroimaging, Clinical &Translational Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Michael D GregorySection on Integrative Neuroimaging, Clinical &Translational Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
José A ApudSection on Integrative Neuroimaging, Clinical &Translational Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Karen F BermanSection on Integrative Neuroimaging, Clinical &Translational Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
National Institutes of Health · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007198 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHI, NEIL C, INSEL, PAUL A · 1985 to 2024
$29.3M
Imaging of Neuropsychiatric Disorders with Developmental and Genetic MechanismsZIAMH002652 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI BERMAN, KAREN FAITH · 2009 to 2025
$17.3M
NIGMS NIH HHS T32 GM007198
6 · The paper itself

Abstract

Standard-of-care biological treatment of schizophrenia remains dependent upon antipsychotic medications, which demonstrate D

Indexed as

Corpus StriatumAdolescentAdultAgedAntipsychotic AgentsDihydroxyphenylalanineDopamineDose-Response Relationship, DrugFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedOxygen RadioisotopesPositron-Emission TomographyAntipsychotic AgentsDihydroxyphenylalanineDopaminefluorodopa F 18Oxygen-15Oxygen RadioisotopesWater

Identifiers

PMID28387222
PMCPMC5603816
OpenAlexW2604875756

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.