ArticleeLife2017
Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 72 citations in OpenAlex.
- Review
- Astrocyte activation in the ventrolateral medulla modulates breathing and arousal states.Nature communications · 2026Article
- Nocturnal hypercapnia in obstructive sleep apnoea and obesity hypoventilation: from pathophysiology to measurement and treatment.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Oxytocinergic signalling in the respiratory parafacial region increases the activity of chemosensitive neurons and respiratory output.The Journal of physiology · 2025Article
- Retrotrapezoid nucleus chemoreception: mechanisms of function and contributions to disordered breathing in disease.Trends in neurosciences · 2025Review
- Update on vascular control of central chemoreceptors.Experimental physiology · 2024Review
- Loss-of-function of chemoreceptor neurons in the retrotrapezoid nucleus: What have we learned from it?Respiratory physiology & neurobiology · 2024Article
- Kir4.1 channels contribute to astrocyte COCommunications biology · 2024Article
- The Coding Logic of Interoception.Annual review of physiology · 2024Review
- The astrocytic NaThe Journal of physiology · 2023Article
- Criteria for central respiratory chemoreceptors: experimental evidence supporting current candidate cell groups.Frontiers in physiology · 2023Review
- Article
- Putative Roles of Astrocytes in General Anesthesia.Current neuropharmacology · 2022Review
- Central respiratory chemoreception.Handbook of clinical neurology · 2022Review
- Potential Role of the Retrotrapezoid Nucleus in Mediating Cardio-Respiratory Dysfunction in Heart Failure With Preserved Ejection Fraction.Frontiers in physiology · 2022Review
- Role of astrocytes in rhythmic motor activity.Physiological reports · 2021Review
- The retrotrapezoid nucleus and the neuromodulation of breathing.Journal of neurophysiology · 2021Review
- Machine learning-based data analytic approaches for evaluating post-natal mouse respiratory physiological evolution.Respiratory physiology & neurobiology · 2021Article
- Vascular control of the COeLife · 2020Article
- Isoflurane inhibits a Kir4.1/5.1-like conductance in neonatal rat brainstem astrocytes and recombinant Kir4.1/5.1 channels in a heterologous expression system.Journal of neurophysiology · 2020Article
Corrections and comments
- Commented on by
Authors and funding
11 authors at 3 institutions in 3 countries.
Virginia E HawkinsDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.ORCID 0000-0001-9505-6776
Ana C TakakuraDepartment of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Ashley TrinhDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.
Milene R Malheiros-LimaDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Colin M ClearyDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.
Ian C WenkerDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.
Todd DubreuilDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.
Elliot M RodriguezDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.
Mark T NelsonDepartment of Pharmacology, College of Medicine, University of Vermont, Burlington, United States.
Thiago S MoreiraDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Daniel K MulkeyDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.ORCID 0000-0002-7040-3927
University of Connecticut · USUniversidade de São Paulo · BRUniversity of Vermont · US
Funding
Impact of SAH on Parenchymal Arterioles and Neurovascular CouplingP01HL095488 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HEPPNER, THOMAS · 2010 to 2014
$11.4MGlial chemosensitivity: pH sensing and interactions with neuronal chemoreceptorsR01HL104101 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI MULKEY, DANIEL K, OLSEN, MICHELLE L · 2010 to 2024
$5.5MCa2+ Sparks and Urinary Bladder Smooth Muscle ExcitabilityR37DK053832 · NIDDK · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2008 to 2017
$3.4MCA++ SPARKS &URINARY BLADDER SMOOTH MUSCLE EXCITABILITYR01DK053832 · NIDDK · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI NELSON, MARK T · 1998 to 2006
$2.0MRegulations of Myoendothelial Function By Signaling Microdomains in HypertensionR01HL121706 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2014 to 2017
$1.6MK+ sensing & electrical signaling by Kir channels in brain vasculatureR01HL131181 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2016 to 2018
$1.4MDefining Astrocyte Heterogeneity in the Retrotrapezoid NucleusF32HL126381 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI HAWKINS, VIRGINIA · 2015 to 2016
$124kNHLBI NIH HHS F32 HL126381NHLBI NIH HHS P01 HL095488NHLBI NIH HHS R01 HL104101NHLBI NIH HHS R01 HL121706NHLBI NIH HHS R01 HL131181NIDDK NIH HHS R01 DK053832NIDDK NIH HHS R37 DK053832
Abstract
Cerebral blood flow is highly sensitive to changes in CO
Indexed as
RespirationVasodilationAnimalsBlood VesselsBrain StemCarbon DioxideCerebrovascular CirculationNeuronsProtonsRatsReceptors, PurinergicCarbon DioxideProtonsReceptors, PurinergicarterioleATPbreathingchemoreceptionneurosciencerat
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.