Evidence map›Paper›PMID 28387157›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

Bone morphogenetic protein-9 increases the functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier via the activin receptor-like kinase-1 receptor.

Wazir Abdullahi, Hrvoje Brzica, Kathryn Ibbotson, Thomas P Davis, Patrick T Ronaldson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-Drug metabolism and disposition: the biological fate of chemicals · 2022
    Article
  5. Review
  6. Dysregulation of BMP, Wnt, and Insulin Signaling in Fragile X Syndrome.Frontiers in cell and developmental biology · 2022
    Review
  7. Article
  8. Understanding the brain uptake and permeability of small molecules through the BBB: A technical overview.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Review
  9. Article
  10. Review
  11. The Roles of TGF-β Signaling in Cerebrovascular Diseases.Frontiers in cell and developmental biology · 2020
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wazir Abdullahi1 Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA.
Hrvoje Brzica1 Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA.
Kathryn Ibbotson2 Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, USA.
Thomas P Davis1 Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA.
Patrick T Ronaldson1 Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA.
University of Arizona · US

Funding

BLOOD BRAIN BARRIER CHANGES INDUCED BY PAINR01NS042652 · NINDS · UNIVERSITY OF ARIZONA · PI DAVIS, THOMAS PAUL · 2002 to 2017
$7.6M
BLOOD TO CNS UPTAKE OF OPIOID PEPTIDE DRUGSR01DA011271 · NIDA · UNIVERSITY OF ARIZONA · PI DAVIS, THOMAS PAUL · 1997 to 2014
$4.4M
Targeting Blood-Brain Barrier Transporters to Treat Ischemic StrokeR01NS084941 · NINDS · UNIVERSITY OF ARIZONA · PI RONALDSON, PATRICK THOMAS · 2014 to 2024
$4.4M
NIDA NIH HHS R01 DA011271NINDS NIH HHS R01 NS042652NINDS NIH HHS R01 NS084941
6 · The paper itself

Abstract

Targeting uptake transporters such as organic anion transporting polypeptide 1a4 (Oatp1a4) at the blood-brain barrier (BBB) can facilitate central nervous system (CNS) drug delivery. Effective blood-to-brain drug transport via this strategy requires characterization of mechanisms that modulate BBB transporter expression and/or activity. Here, we show that activation of activin receptor-like kinase (ALK)-1 using bone morphogenetic protein (BMP)-9 increases Oatp1a4 protein expression in rat brain microvessels in vivo. These data indicate that targeting ALK1 signaling with BMP-9 modulates BBB Oatp1a4 expression, presenting a unique opportunity to optimize drug delivery and improve pharmacotherapy for CNS diseases.

Indexed as

Activin ReceptorsAnimalsBiological TransportBlood-Brain BarrierDrug Delivery SystemsFemaleGene Expression RegulationGrowth Differentiation Factor 2MicrovesselsOrganic Anion TransportersPerfusionPyrazolesPyrimidinesRats, Sprague-DawleySignal TransductionActivin ReceptorsAcvrl1 protein, ratGrowth Differentiation Factor 2LDN 193189Organic Anion TransportersPyrazolesPyrimidinesSlco1a4 protein, ratBasic scienceblood–brain barrierendotheliumpharmacologyvascular biology

Identifiers

PMID28387157
PMCPMC5531361
OpenAlexW2604511409

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.