ArticleCephalalgia : an international journal of headache2017
Altered pupillary light response scales with disease severity in migrainous photophobia.
Article in Cephalalgia : an international journal of headache, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- Spectral Composition of Ambient White Light Modulates Photophobia and Headache Intensity During Migraine Attacks.Neurology and therapy · 2026Article
- Amplifying and ameliorating light avoidance in mice with photoreceptor targeting and calcitonin gene-related peptide sensitization.Headache · 2026Article
- Heightened visual light sensitivity discomfort measured by the ocular photosensitivity analyzer is associated with chronic ocular pain.The ocular surface · 2025Article
- Pattern-induced visual discomfort and its cumulative effects revealed by pupillary measures.Frontiers in human neuroscience · 2025Article
- Update on Clinical Trial Endpoints in Gene Therapy Trials for Inherited Retinal Diseases.Journal of clinical medicine · 2024Review
- Increased presynaptic excitability in a migraine with aura mutation.Brain : a journal of neurology · 2024Article
- Validation of the Utah Photophobia Symptom Impact Scale (version 2) as a headache-specific photophobia assessment tool.Headache · 2023Article
- Headache and Autonomic Dysfunction: a Review.Current neurology and neuroscience reports · 2022Review
- Photophobia in headache disorders: characteristics and potential mechanisms.Journal of neurology · 2022Review
- Visual photosensitivity threshold and objective photosensitivity luminance in healthy human eyes assessed using an automated ocular photosensitivity analyser: a step towards translation of a clinical tool for assessing photophobia.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2022Article
- Eye Movements in Mild Traumatic Brain Injury: Ocular Biomarkers.Journal of eye movement research · 2022Article
- Reflexive Eye Closure in Response to Cone and Melanopsin Stimulation: A Study of Implicit Measures of Light Sensitivity in Migraine.Neurology · 2021Article
- Photophobia in migraine: A symptom cluster?Cephalalgia : an international journal of headache · 2021Review
- Photophobia and allodynia in persistent post-traumatic headache are associated with higher disease burden.Cephalalgia : an international journal of headache · 2021Article
- Quantitative Infrared Pupillometry in Nonconvulsive Status Epilepticus.Neurocritical care · 2021Observational
- Synergistic but separable sensory changes in postural tachycardia syndrome and chronic migraine.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Neuro-ophthalmologic Findings in Visual Snow Syndrome.Journal of clinical neurology (Seoul, Korea) · 2020Article
- Time Course of Autonomic Symptoms in Postural Orthostatic Tachycardia Syndrome (POTS) Patients: Two-Year Follow-Up Results.International journal of environmental research and public health · 2020Article
- Selective amplification of ipRGC signals accounts for interictal photophobia in migraine.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Investigation of light-induced lacrimation and pupillary responses in episodic migraine.PloS one · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Background Autonomic dysfunction and light sensitivity are core features of the migraine attack. Growing evidence also suggests changes in these parameters between attacks. Though sensory and autonomic responses likely interact, they have not been studied together across the spectrum of disease in migraine. Methods We performed digital infrared pupillometry while collecting interictal photophobia thresholds (PPT) in 36 migraineurs (14 episodic; 12 chronic; 10 probable) and 24 age and sex-matched non-headache controls. Quantitative pupillary light reflexes (PLR) were assessed in a subset of subjects, allowing distinction of sympathetic vs parasympathetic pupillary function. A structured questionnaire was used to ascertain migraine diagnosis, headache severity, and affective symptoms. Results Photophobia thresholds were significantly lower in migraineurs than controls, and were lowest in chronic migraine, consistent with a disease-related gradient. Lower PPT correlated with smaller dark-adapted pupil size and larger end pupil size at PPT, which corresponded to a reduced diameter change. On PLR testing, measures of both parasympathetic constriction and sympathetic re-dilation were reduced in migraineurs with clinically severe migraine. Conclusions In summary, we show that severity of photophobia in migraine scales with disease severity, in association with shifts in pupillary light responses. These alterations suggest centrally mediated autonomic adaptations to chronic light sensitivity.
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