Evidence map›Paper›PMID 28386718›Full record

ArticleEuropean radiology2017

Globus pallidus MR signal abnormalities in children with chronic liver disease and/or porto-systemic shunting.

Sylviane Hanquinet, Claire Morice, Delphine S Courvoisier, Vladimir Cousin, Mehrak Anooshiravani, Laura Merlini, Valérie A McLin

Registry-linked trialAbstract read
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In one paragraph

Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06041906 (International Registry of Congenital Portosystemic Shunts), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06041906 enrolling by invitationnot on this mapstarted 2018, after this paper: background citation

International Registry of Congenital Portosystemic Shunts (IRCPSS) - A Multi-centre, Retrospective and Prospective Registry of Neonates, Children and Adults With Congenital Portosystemic Shunts

Typeobservational_patient_registrySponsorProf. Valérie Mc LinRan2018 to 2028Enrolled500ConditionsCongenital Portosystemic Shunt, CPSS (Congenital Portosystemic Shunt)ArmsShunt Closure
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sylviane HanquinetDepartment of Pediatric Radiology, University Hospital of Geneva, Geneva, Switzerland. sylviane.hanquinet-ginter@hcuge.ch.
Claire MoriceSwiss Center for Liver Disease in Children, University Hospital of Geneva, Geneva, Switzerland.
Delphine S CourvoisierDivision of Quality of Care, University Hospital of Geneva, Geneva, Switzerland.
Vladimir CousinSwiss Center for Liver Disease in Children, University Hospital of Geneva, Geneva, Switzerland.
Mehrak AnooshiravaniDepartment of Pediatric Radiology, University Hospital of Geneva, Geneva, Switzerland.
Laura MerliniDepartment of Pediatric Radiology, University Hospital of Geneva, Geneva, Switzerland.
Valérie A McLinSwiss Center for Liver Disease in Children, University Hospital of Geneva, Geneva, Switzerland.
University Hospital of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDetection of subclinical hepatic encephalopathy in children is difficult. We aimed to assess the changes in imaging of the central nervous system in children with chronic liver disease using MR imaging, diffusion, and

methodsForty three children with chronic liver disease and/or porto-systemic shunting (111.4±56.9 months) and 24 controls (72.0±51.8 months) underwent brain MRI/spectroscopy on a 1.5T to examine T1, T2, ADC, Cho/Cr, ml/Cr, Glx/Cr ratio spectroscopy in the globus pallidus. Patients were divided into 3 groups according to the ratios of globus pallidus/putamen T1 signal : isointense (i), hyperintense (h), much more hyperintense (h+). The relationship with clinical and biological data was analyzed.

resultsT1 signal intensity and ml/Cr were significantly different between controls and group h+ (p=0.001). ADC did not differ significantly between groups. Age correlated strongly with the presence of a T1 signal ratio (p > 0.001). There was no correlation between imaging findings and biological parameters.

conclusionsIn children with chronic liver disease and/or porto-systemic shunting, the presence of a hyperintense T1 signal in the globus pallidus correlated strongly with age. Biological and clinical parameters were not predictive of these changes. MRI may become a useful screening tool for hepatic encephalopathy in children. KEY POINTS: • Children with chronic liver disease should undergo brain MRI during their follow-up • T1 hyperintensity of globus pallidus is suggestive of liver-related CNS involvement • MRS mI/Cr is decreased in children with chronic liver disease • Biological parameters (ammonium) were not predictive of hepatic encephalopathy • Duration of chronic liver disease may be causative the hepatic encephalopathy.

Indexed as

AdolescentCase-Control StudiesChildChild, PreschoolChronic DiseaseCross-Sectional StudiesDiffusion Tensor ImagingFemaleGlobus PallidusHepatic EncephalopathyHumansInfantLiver DiseasesMagnetic Resonance ImagingMaleChildChronic liver diseaseHepatic encephalopathyPortosystemic shuntingT1 hyperintense

Identifiers

PMID28386718
OpenAlexW2604533794

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.