Evidence map›Paper›PMID 28386566›Full record

Observational studyJournal of diabetes research2017

Irisin: A Potential Link between Physical Exercise and Metabolism-An Observational Study in Differently Trained Subjects, from Elite Athletes to Sedentary People.

Stefano Benedini, Elena Dozio, Pietro Luigi Invernizzi, Elena Vianello, Giuseppe Banfi, Ileana Terruzzi, Livio Luzi, Massimiliano Marco Corsi Romanelli

Abstract readObservational Study
In one paragraph

Observational study in Journal of diabetes research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stefano BenediniDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, Via L. Mangiagalli 31, 20133 Milan, Italy; Endocrinology Unit, IRCCS Policlinico San Donato, Via R. Morandi 30, San Donato Milanese, 20097 Milan, Italy.ORCID 0000-0003-0661-1657
Elena DozioDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, Via L. Mangiagalli 31, 20133 Milan, Italy.ORCID 0000-0001-5833-0780
Pietro Luigi InvernizziDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, Via L. Mangiagalli 31, 20133 Milan, Italy.
Elena VianelloDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, Via L. Mangiagalli 31, 20133 Milan, Italy.
Giuseppe BanfiLaboratory of Experimental Biochemistry and Molecular Biology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.
Ileana TerruzziDiabetes Research Institute, Metabolism, Nutrigenomics and Cellular Differentiation Unit, San Raffaele Scientific Institute, Milan, Italy.
Livio LuziDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, Via L. Mangiagalli 31, 20133 Milan, Italy; Endocrinology Unit, IRCCS Policlinico San Donato, Via R. Morandi 30, San Donato Milanese, 20097 Milan, Italy; Metabolism Research Center, IRCCS Policlinico San Donato, Via R. Morandi 30, San Donato Milanese, 20097 Milan, Italy.ORCID 0000-0003-3183-0552
Massimiliano Marco Corsi RomanelliDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, Via L. Mangiagalli 31, 20133 Milan, Italy; SMEL-1 Laboratory Medicine Unit, IRCCS Policlinico San Donato, Via R. Morandi 30, San Donato Milanese, 20097 Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We compared irisin levels among groups of differently trained healthy individuals to explore the role of irisin as a physiological linker between exercise and metabolic health. Irisin and biochemical parameters of glucose and lipid metabolism were assessed in 70 healthy volunteers stratified for sport performance level into four groups: (1) 20 elite athletes of national level, (2) 20 subelite athletes of local level, (3) 20 recreational athletes, and (4) 10 sedentary subjects. All biochemical parameters were within the ranges of normality. Fasting glucose, HOMA-IR, and total cholesterol levels were inversely related to the degree of physical activity. HbA1c was higher in elite athletes compared to all the other groups (

Indexed as

AthletesExerciseAdolescentAdultAnticoagulantsBlood GlucoseCase-Control StudiesCholesterolFemaleFibronectinsGlucoseHealthy VolunteersHumansInsulinInsulin ResistanceLipid MetabolismAnticoagulantsBlood GlucoseCholesterolFibronectinsFNDC5 protein, humanGlucoseInsulin

Identifiers

PMID28386566
PMCPMC5366762

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.