ReviewFrontiers in bioengineering and biotechnology2017
Biofabrication and Bone Tissue Regeneration: Cell Source, Approaches, and Challenges.
Review in Frontiers in bioengineering and biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed.
- MicroRNA-driven periodontal immune homeostasis and tissue regeneration: from regulatory networks to engineering translation.Frontiers in immunology · 2026Review
- Tailoring cell behaviour by surface micropatterning and interconnected porous structure of gelatin/nano-silica/PLGA 3D composite scaffold for bone tissue engineering.RSC advances · 2025Article
- Investigation of Angiogenic Potential in CD146-Positive Stem Cells Derived from Human Exfoliated Deciduous Teeth.International journal of molecular sciences · 2025Article
- Effective Bone Tissue Fabrication Using 3D-Printed Citrate-Based Nanocomposite Scaffolds Laden with BMP9-Stimulated Human Urine Stem Cells.ACS applied materials & interfaces · 2025Article
- Personalized bioceramic grafts for craniomaxillofacial bone regeneration.International journal of oral science · 2024Review
- Site-specific periosteal cells with distinct osteogenic and angiogenic characteristics.Clinical oral investigations · 2023Article
- The Diamond Concept Enigma: Recent Trends of Its Implementation in Cross-linked Chitosan-Based Scaffolds for Bone Tissue Engineering.ACS applied bio materials · 2023Review
- The Role of Extracellular Matrix (ECM) Adhesion Motifs in Functionalised Hydrogels.Molecules (Basel, Switzerland) · 2023Review
- Article
- Hydroxyapatite or Fluorapatite-Which Bioceramic Is Better as a Base for the Production of Bone Scaffold?-A Comprehensive Comparative Study.International journal of molecular sciences · 2023Article
- Biofabrication of functional bone tissue: defining tissue-engineered scaffolds from nature.Frontiers in bioengineering and biotechnology · 2023Review
- Hydroxyapatite-Tethered Peptide Hydrogel Promotes Osteogenesis.Gels (Basel, Switzerland) · 2022Article
- Demonstrating the Potential of Using Bio-Based Sustainable Polyester Blends for Bone Tissue Engineering Applications.Bioengineering (Basel, Switzerland) · 2022Article
- Airbrushed Polysulfone (PSF)/Hydroxyapatite (HA) Nanocomposites: Effect of the Presence of Nanoparticles on Mechanical Behavior.Polymers · 2022Article
- Cell-Based Double-Screening Method to Identify a Reliable Candidate for Osteogenesis-Targeting Compounds.Biomedicines · 2022Article
- High resolution DLP stereolithography to fabricate biocompatible hydroxyapatite structures that support osteogenesis.PloS one · 2022Article
- Mineralizing Coating on 3D Printed Scaffolds for the Promotion of Osseointegration.Frontiers in bioengineering and biotechnology · 2022Article
- Conductive Scaffolds for Bone Tissue Engineering: Current State and Future Outlook.Journal of functional biomaterials · 2021Review
- New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments.APL bioengineering · 2021Review
- In Vivo Biological Behavior of Polymer Scaffolds of Natural Origin in the Bone Repair Process.Molecules (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The growing occurrence of bone disorders and the increase in aging population have resulted in the need for more effective therapies to meet this request. Bone tissue engineering strategies, by combining biomaterials, cells, and signaling factors, are seen as alternatives to conventional bone grafts for repairing or rebuilding bone defects. Indeed, skeletal tissue engineering has not yet achieved full translation into clinical practice because of several challenges. Bone biofabrication by additive manufacturing techniques may represent a possible solution, with its intrinsic capability for accuracy, reproducibility, and customization of scaffolds as well as cell and signaling molecule delivery. This review examines the existing research in bone biofabrication and the appropriate cells and factors selection for successful bone regeneration as well as limitations affecting these approaches. Challenges that need to be tackled with the highest priority are the obtainment of appropriate vascularized scaffolds with an accurate spatiotemporal biochemical and mechanical stimuli release, in order to improve osseointegration as well as osteogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.