Evidence map›Paper›PMID 28386464›Full record

ReviewInterventional medicine & applied science2016

The microscopic and ultramicroscopic changes in the skeletal muscles, caused by heavy metal salts.

Alexey Tymoshenko, Gennadii Tkach, Vitalii Sikora, Valentina Bumeister, Ihor Shpetnyi, Mykola Lyndin, Olena Maksymova, Anna Maslenko

Abstract readReview
In one paragraph

Review in Interventional medicine & applied science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexey TymoshenkoDepartment of Normal Anatomy with a Topographical Anatomy and Operational Surgery Course, Sumy State University , Sumy, Ukraine.
Gennadii TkachDepartment of Normal Anatomy with a Topographical Anatomy and Operational Surgery Course, Sumy State University , Sumy, Ukraine.
Vitalii SikoraDepartment of Normal Anatomy with a Topographical Anatomy and Operational Surgery Course, Sumy State University , Sumy, Ukraine.
Valentina BumeisterDepartment of Normal Anatomy with a Topographical Anatomy and Operational Surgery Course, Sumy State University , Sumy, Ukraine.
Ihor ShpetnyiDepartment of Applied Physics, Sumy State University , Sumy, Ukraine.
Mykola LyndinDepartment of Pathology, Sumy State University , Sumy, Ukraine.
Olena MaksymovaSumy State University , Sumy, Ukraine.
Anna MaslenkoSumy State University , Sumy, Ukraine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe article is devoted to study the structural changes in the skeletal muscles caused by heavy metal salts. MATERIALS AND

methodsThe study was conducted on 72 mature male rats. The experimental groups were given to drink water with combinations of heavy metal salts for one, two and three months. This type of water is typical for the water basins in the northern districts of the Sumy region. The study of morphological changes in the striated muscles was concluded using light and scanning electron microscopy.

resultsThe data analysis revealed that a prolonged duration of negative factor could intensify sclerotic and edematous processes. The structure of muscle fibers was destroyed, nuclei were deformed and placed irregularly, and many petechial hemorrhages occurred. Besides, cross-striation was irregular, I and A bands were deformed and destroyed, H band was hardly visualized. The inner mitochondrial membrane and cristae become deformed. The symplastic nuclei were placed irregularly within sarcoplasm. Besides, they were swollen. Against swollen and enlarged symplastic nuclei, pyknotic nuclei were also found. The structures of sarcoplasmic reticulum were mainly dilated with deformed and ruptured areas.

conclusionOur study approves that high concentrations of heavy metal salts have a destructive influence on the skeletal striated muscles.

Indexed as

electron microscopeheavy metal saltsratsstriated muscleultrastructure

Identifiers

PMID28386464
PMCPMC5370355

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.