ArticleRoyal Society open science2017
Immune system stimulation by the native gut microbiota of honey bees.
Article in Royal Society open science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 229 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
229 citing papers in PubMed.
- Species-specific structuring of gut bacterial and fungal communities in honey bees Apis cerana and Apis mellifera.Antonie van Leeuwenhoek · 2026Article
- Calcineurin-dependent 20E signaling pathway enhances attacin expression to prime the immunity of Helicoverpa armigera against Bacillus thuringiensis Cry1Ac toxin.PLoS pathogens · 2026Article
- From Pollen to Pathogen Defense: How Pollen Chemical Quality Impacts Deformed Wing Virus Infection and Survival in Honey Bees.Viruses · 2026Review
- Bacterial supplementation shapes honey bee gut microbiota and host metabolism under controlled and field conditions.mSystems · 2026Article
- Contrasting Toxicity Classes Differentially Affect Gut Microbiota Composition in Honey Bees.Insects · 2026Article
- Dietary pollen and carbohydrate sources influence longevity, physiology, and gut microbiota in honey bee (Apis mellifera).Scientific reports · 2026Article
- The interplay between insect gut microbiota and host immunity in the development and dissemination of antibiotic resistance.Folia microbiologica · 2026Review
- Review
- Gut microbiota-derived butyrate primes systemic immunity in honey bees by mediating lipid metabolic reprogramming.Nature communications · 2026Article
- Melatonin as a Potential Dietary Supplement to Counteract Glyphosate-Induced Decline in Honeybee Populations.Insects · 2026Article
- A non-invasive method for profiling the gut microbiome and virome of honey bee queens.Scientific reports · 2026Article
- Host and microbial factors influence bacterial colonization of the honey bee gut.The ISME journal · 2026Article
- Gut Microbiome Differences Across Mixed-Sex and Female-Only Social Rearing Regimes in Female Field CricketsInsects · 2026Article
- Deformed Wing Virus infection induces immunosuppression and gut dysbiosis in honey bees.Animal microbiome · 2026Article
- The honeybee gut microbiome: a novel multidimensional model of antimicrobial resistance transmission and immune homeostasis from environmental interactions to health regulation.FEMS microbiology reviews · 2026Review
- Gut microbiota of Brazilian Melipona stingless bees: Dominant members and their localization in different gut regions.PloS one · 2026Article
- Host-associated beneficial gut microbiota boosts induced immunity and limits immune deployment costs in bumblebees.The Journal of animal ecology · 2026Article
- Article
- Gut bacteria induce heterologous immune priming in Rhodnius prolixus encompassing both humoral and cellular immune responses.PLoS pathogens · 2025Article
- Synergistic host-parasitoid antimicrobial peptide interactions ensure the survival of parasitized hosts.Virulence · 2025Article
169 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Gut microbial communities can greatly affect host health by modulating the host's immune system. For many important insects, however, the relationship between the gut microbiota and immune function remains poorly understood. Here, we test whether the gut microbial symbionts of the honey bee can induce expression of antimicrobial peptides (AMPs), a crucial component of insect innate immunity. We find that bees up-regulate gene expression of the AMPs apidaecin and hymenoptaecin in gut tissue when the microbiota is present. Using targeted proteomics, we detected apidaecin in both the gut lumen and the haemolymph; higher apidaecin concentrations were found in bees harbouring the normal gut microbiota than in bees lacking gut microbiota. In
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.