ArticleAmerican journal of translational research2017
GYY4137 stimulates osteoblastic cell proliferation and differentiation
Article in American journal of translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
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- The Role of Gasotransmitter-Dependent Signaling Mechanisms in Apoptotic Cell Death in Cardiovascular, Rheumatic, Kidney, and Neurodegenerative Diseases and Mental Disorders.International journal of molecular sciences · 2023Review
- Reactive sulfur and selenium species in the regulation of bone homeostasis.Free radical biology & medicine · 2022Review
- Balneotherapy year in review 2021: focus on the mechanisms of action of balneotherapy in rheumatic diseases.Environmental science and pollution research international · 2022Review
- Effects of Sodium Chloride-Rich Mineral Water on Intestinal Epithelium. Experimental Study.International journal of environmental research and public health · 2021Article
- Association of Hydrogen Sulfide with Femoral Bone Mineral Density in Osteoporosis Patients: A Preliminary Study.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Article
- From in vitro research to real life studies: an extensive narrative review of the effects of balneotherapy on human immune response.Sport sciences for health · 2021Review
- Antibacterial peptides inhibit MC3T3-E1 cells apoptosis induced by TNF-α through p38 MAPK pathway.Annals of translational medicine · 2020Article
- A comprehensive analysis to understand the mechanism of action of balneotherapy: why, how, and where they can be used? Evidence from in vitro studies performed on human and animal samples.International journal of biometeorology · 2020Review
- Hydrogen Sulfide in Bone Tissue Regeneration and Repair: State of the Art and New Perspectives.International journal of molecular sciences · 2019Review
- GYY4137 a HIranian journal of basic medical sciences · 2019Article
- Experimental research into the potential therapeutic effect of GYY4137 on Ovariectomy-induced osteoporosis.Cellular & molecular biology letters · 2018Article
- The expression of cystathionine gamma-lyase is regulated by estrogen receptor alpha in human osteoblasts.Oncotarget · 2017Article
- Orexin-A protects SH-SY5Y cells against HInternational journal of immunopathology and pharmacologyArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOxidative stress plays a critical role in the development of osteoporosis. Hydrogen sulfide (H
methodsThe MC3T3-E1 osteoblast-like cell line was cultured in plate. After pretreatment with GYY4137 (100 µM) for 30 min, the cells were washed twice with PBS solution and then incubated in freshly prepared low serum medium containing 400 μM H
resultsWe found in the present study that GYY4137, a slow H
conclusionsGYY4137 stimulates osteoblastic cell proliferation and bone differentiation via an ERK1/2-dependent anti-oxidant mechanism. Our findings suggest that GYY4137 may have a potentially therapeutic value for osteoporosis.
Indexed as
Identifiers
28386344PMC5376009W2982297672What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.