Evidence map›Paper›PMID 28386318›Full record

ArticleAmerican journal of translational research2017

PAX4 promotes PDX1-induced differentiation of mesenchymal stem cells into insulin-secreting cells.

Lifa Xu, Congjing Xu, Shuping Zhou, Xueke Liu, Jian Wang, Xinkuang Liu, Suping Qian, Yingru Xin, Yi Gao, Yongqiang Zhu and 1 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. iScience · 2025
    Article
  3. Review
  4. Article
  5. Pax4 in Health and Diabetes.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Lifa XuStem Cell Engineering Research Center, School of Medical, Anhui University of Science & Technology Huainan 232001, P.R. China.
Congjing XuDepartment of Respiration, Tumour Hospital of Affiliated Huainan Oriental Hospital Group, Anhui University of Science and Technology Huainan 232035, P.R. China.
Shuping ZhouHuainan First People's Hospital and First Affiliated Hospital of Medical College, Anhui University of Science & Technology Huainan 232001, P.R. China.
Xueke LiuStem Cell Engineering Research Center, School of Medical, Anhui University of Science & Technology Huainan 232001, P.R. China.
Jian WangStem Cell Engineering Research Center, School of Medical, Anhui University of Science & Technology Huainan 232001, P.R. China.
Xinkuang LiuHuainan First People's Hospital and First Affiliated Hospital of Medical College, Anhui University of Science & Technology Huainan 232001, P.R. China.
Suping QianDepartment of Respiration, Tumour Hospital of Affiliated Huainan Oriental Hospital Group, Anhui University of Science and Technology Huainan 232035, P.R. China.
Yingru XinDepartment of Respiration, Tumour Hospital of Affiliated Huainan Oriental Hospital Group, Anhui University of Science and Technology Huainan 232035, P.R. China.
Yi GaoHuainan First People's Hospital and First Affiliated Hospital of Medical College, Anhui University of Science & Technology Huainan 232001, P.R. China.
Yongqiang ZhuDepartment of Medical Genetics, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, P.R. China.
Xiaolong TangStem Cell Engineering Research Center, School of Medical, Anhui University of Science & Technology Huainan 232001, P.R. China.
Anhui University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A shortage of postmortem pancreatic tissue for islet isolation impedes the application of cell replacement therapy in patients with diabetes. As an alternative for islet cell transplantation, transcription factors, including PDX1, PAX4, and neurogenin-3, that aid in the formation of insulin-producing β cells during development have been investigated. The present study evaluated the effects of PAX4 and PDX1 on the differentiation of mesenchymal stem cells (MSCs) into insulin-producing β-like cells

Indexed as

differentiationMSCpancreatic β cellPAX4PDX1

Identifiers

PMID28386318
PMCPMC5375983
OpenAlexW2972967746

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.