ArticleFrontiers in physiology2017
Bifurcation in Blood Oscillatory Rhythms for Patients with Ischemic Stroke: A Small Scale Clinical Trial using Laser Doppler Flowmetry and Computational Modeling of Vasomotion.
Article in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Multimodal assessment of arterial stiffness using photoplethysmography and laser Doppler flowmetry.NPJ cardiovascular health · 2026Article
- Review
- Arterial-wall origin and transient dynamics of flow- and vaso-motion activities in the awake mouse brain revealed by laser speckle contrast imaging.Neurophotonics · 2025Article
- Wearable laser Doppler flowmetry for non-invasive assessment of diabetic foot microcirculation: methodological considerations and clinical implications.Journal of biomedical optics · 2024Article
- Asymmetry of Characteristics of the Right-Left Hemodynamic Balance of Microcirculation in the Temporal Skin Areas of the Head in Young Male and Female Subjects.Bulletin of experimental biology and medicine · 2023Article
- Non-Invasive Continuous Optical Monitoring of Cerebral Blood Flow after Traumatic Brain Injury in Mice Using Fiber Camera-Based Speckle Contrast Optical Spectroscopy.Brain sciences · 2023Article
- Cerebral Circulation and Brain Temperature during an Ultra-Short Session of Dry Immersion in Young Subjects.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023Article
- A Method for Assessing Stability of Regional Blood Circulation in Humans.Bulletin of experimental biology and medicine · 2022Article
- Body Position Affects Capillary Blood Flow Regulation Measured with Wearable Blood Flow Sensors.Diagnostics (Basel, Switzerland) · 2021Article
- Wearable Laser Doppler Flowmetry Sensor: A Feasibility Study with Smoker and Non-Smoker Volunteers.Biosensors · 2020Article
- Multimodal Optical Diagnostics of the Microhaemodynamics in Upper and Lower Limbs.Frontiers in physiology · 2019Article
- Application of wavelet analysis to detect dysfunction in cerebral blood flow autoregulation during experimental hyperhomocysteinaemia.Lasers in medical science · 2018Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe application of spectral analysis of laser Doppler flowmetry (LDF) signals to investigation of cerebrovascular haemodynamics in patients with post-acute ischemic stroke (AIS) and cerebrovascular insufficiency. LDF was performed from 3 to 7 days after the onset of AIS on forehead in the right and left supraorbital regions in patients. Analysis of LDF signals showed that perfusion in the microvasculature in AIS patients was lower than that in patients with cerebrovascular insufficiency. As a result of wavelet analysis of the LDF signals we obtained activation of the vasomotion in the frequency range of myogenic oscillation of 0.1 Hz and predominantly nutritive regime microcirculation after systemic thrombolytic therapy of the AIS patients. In case of significant stroke size, myogenic activity, and nutritive pattern microhaemodynamics were reduced, in some cases non-nutritive pattern and/or venular stasis was revealed. Wavelet analysis of the LDF signals also showed asymmetry in wavelet spectra of the LDF signals obtained in stroke-affected and unaffected hemispheres in the AIS patients. A mechanism underlying the observed asymmetry was analyzed by computational modeling of vasomotion developed in Arciero and Secomb (2012). We applied this model to describe relaxation oscillation of arteriole diameter which is forced by myogenic oscillation induced by synchronous calcium oscillation in vascular smooth muscle cells. Calculation showed that vasomotion frequency spectrum at the low-frequency range (0.01 Hz) is reciprocally modulated by myogenic oscillation (0.1 Hz) that correlates with experimental observation of inter-hemispheric variation in the LDF spectrum.
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