ArticleFrontiers in behavioral neuroscience2017
Deep Brain Stimulation of the Nucleus Accumbens Core Affects Trait Impulsivity in a Baseline-Dependent Manner.
Article in Frontiers in behavioral neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The Anatomical Connections of Nucleus Accumbens with Brainstem and Cerebellum in the Rat and Human Subjects.Cerebellum (London, England) · 2026Article
- Regulation of autism-related self-injurious behavior by electrical stimulation of corticostriatal circuits in mice and humans.Science advances · 2026Article
- Involvement of a stress-responsive orbito-striatal projection in impulsive action in male rats.The international journal of neuropsychopharmacology · 2025Article
- Pramipexole restores behavioral inhibition in highly impulsive rats through a paradoxical modulation of frontostriatal networks.Translational psychiatry · 2024Article
- Development and validation of an automatic classification algorithm for the diagnosis of Alzheimer's disease using a high-performance interpretable deep learning network.European radiology · 2023Article
- Variation in inhibitory control does not influence social rank, foraging efficiency, or risk taking, in red junglefowl females.Animal cognition · 2022Article
- How Inhibitory Control Relates to Positive and Negative Affective States in Red Junglefowl.Frontiers in veterinary science · 2022Article
- An automated home-cage-based 5-choice serial reaction time task for rapid assessment of attention and impulsivity in rats.Psychopharmacology · 2019Article
- Efficacy of Invasive and Non-Invasive Brain Modulation Interventions for Addiction.Neuropsychology review · 2019Review
- Deep brain stimulation for obsessive compulsive disorder: A review of results by anatomical target.Mental illness · 2018Article
- Nucleus Accumbens Deep Brain Stimulation in Patients with Substance Use Disorders and Delay Discounting.Brain sciences · 2018Article
- Accumbens connectivity during deep-brain stimulation differentiates loss of control from physiologic behavioral states.Brain stimulationArticle
- Article
- High trait impulsivity potentiates the effects of chronic pain on impulsive behavior.Neurobiology of pain (Cambridge, Mass.)Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deep brain stimulation (DBS) of the nucleus accumbens (NA) is explored as a treatment for refractory psychiatric disorders, such as obsessive-compulsive disorder (OCD), depressive disorder (MDD), and substance use disorder (SUD). A common feature of some of these disorders is pathological impulsivity. Here, the effects of NAcore DBS on impulsive choice and impulsive action, two distinct forms of impulsive behavior, were investigated in translational animal tasks, the delayed reward task (DRT) and five-choice serial reaction time task (5-CSRTT), respectively. In both tasks, the effects of NAcore DBS were negatively correlated with baseline impulsive behavior, with more pronounced effects in the 5-CSRTT. To further examine the effects of DBS on trait impulsive action, rats were screened for high (HI) and low (LI) impulsive responding in the 5-CSRTT. NAcore DBS decreased impulsive, premature responding in HI rats under conventional conditions. However, upon challenged conditions to increase impulsive responding, NAcore DBS did not alter impulsivity. These results strongly suggest a baseline-dependent effect of DBS on impulsivity, which is in line with clinical observations.
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