Evidence map›Paper›PMID 28386119›Full record

ArticleScientific reports2017

Alterations in erythrocyte fatty acid composition in preclinical Alzheimer's disease.

Kathryn Goozee, Pratishtha Chatterjee, Ian James, Kaikai Shen, Hamid R Sohrabi, Prita R Asih, Preeti Dave, Bethany Ball, Candice ManYan, Kevin Taddei and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Lipids and Alzheimer's Disease.International journal of molecular sciences · 2020
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Oligosaccharides fromEvidence-based complementary and alternative medicine : eCAM · 2019
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Kathryn GoozeeAnglicare, Sydney, NSW, Australia.
Pratishtha ChatterjeeSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Ian JamesInstitute for Immunology & Infectious Diseases, Murdoch University, Murdoch, WA, Australia.
Kaikai ShenSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Hamid R SohrabiSchool of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA, Australia.ORCID http://orcid.org/0000-0001-8017-8682
Prita R AsihKaRa Institute of Neurological Diseases, Macquarie Park, NSW, Australia.
Preeti DaveAnglicare, Sydney, NSW, Australia.
Bethany BallKaRa Institute of Neurological Diseases, Macquarie Park, NSW, Australia.
Candice ManYanAnglicare, Sydney, NSW, Australia.
Kevin TaddeiSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Roger ChungDepartment of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.
Manohar L GargNutraceuticals Research Program, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.
Ralph N MartinsSchool of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA, Australia. r.martins@ecu.edu.au.
Edith Cowan University · AUKaRaMinds · AUMacquarie University · AUMurdoch University · AUUniversity of Newcastle Australia · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain and blood fatty acids (FA) are altered in Alzheimer's disease and cognitively impaired individuals, however, FA alterations in the preclinical phase, prior to cognitive impairment have not been investigated previously. The current study therefore evaluated erythrocyte FA in cognitively normal elderly participants aged 65-90 years via trans-methylation followed by gas chromatography. The neocortical beta-amyloid load (NAL) measured via positron emission tomography (PET) using ligand

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesApolipoprotein E4BiomarkersBrainDietary FatsErythrocytesFatty AcidsFemaleHippocampusHumansLipid MetabolismMaleProtein AggregatesAmyloid beta-PeptidesApolipoprotein E4BiomarkersDietary FatsFatty AcidsProtein Aggregates

Identifiers

PMID28386119
PMCPMC5429676
OpenAlexW2600881751

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.