Evidence map›Paper›PMID 28386114›Full record

ArticleScientific reports2017

Avian and human influenza virus compatible sialic acid receptors in little brown bats.

Shubhada K Chothe, Gitanjali Bhushan, Ruth H Nissly, Yin-Ting Yeh, Justin Brown, Gregory Turner, Jenny Fisher, Brent J Sewall, DeeAnn M Reeder, Mauricio Terrones and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

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  9. Article
  10. Glycosylation and the global virome.Molecular ecology · 2023
    Article
  11. Article
  12. Review
  13. Inferring the Urban Transmission Potential of Bat Influenza Viruses.Frontiers in cellular and infection microbiology · 2020
    Review
  14. Article
  15. Review
  16. Article
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Shubhada K ChotheAnimal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA.
Gitanjali BhushanAnimal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA.
Ruth H NisslyAnimal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA.
Yin-Ting YehDepartment of Physics, The Pennsylvania State University, University Park, PA, USA.
Justin BrownAnimal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA.
Gregory TurnerPennsylvania Game Commission, 2001 Elmerton Ave, Harrisburg, PA, USA.
Jenny FisherAnimal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA.
Brent J SewallDepartment of Biology, Temple University, Philadelphia, PA, USA.
DeeAnn M ReederDepartment of Biology, Bucknell University, Lewisburg, PA, USA.
Mauricio TerronesDepartment of Physics, The Pennsylvania State University, University Park, PA, USA.
Bhushan M JayaraoAnimal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA.
Suresh V KuchipudiAnimal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA. skuchipudi@psu.edu.
Pennsylvania State University · USBucknell University · USPennsylvania Game CommissionTemple University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza A viruses (IAVs) continue to threaten animal and human health globally. Bats are asymptomatic reservoirs for many zoonotic viruses. Recent reports of two novel IAVs in fruit bats and serological evidence of avian influenza virus (AIV) H9 infection in frugivorous bats raise questions about the role of bats in IAV epidemiology. IAVs bind to sialic acid (SA) receptors on host cells, and it is widely believed that hosts expressing both SA α2,3-Gal and SA α2,6-Gal receptors could facilitate genetic reassortment of avian and human IAVs. We found abundant co-expression of both avian (SA α2,3-Gal) and human (SA α2,6-Gal) type SA receptors in little brown bats (LBBs) that were compatible with avian and human IAV binding. This first ever study of IAV receptors in a bat species suggest that LBBs, a widely-distributed bat species in North America, could potentially be co-infected with avian and human IAVs, facilitating the emergence of zoonotic strains.

Indexed as

AnimalsChiropteraFluorescent Antibody TechniqueGene ExpressionHumansImmunohistochemistryInfluenza A virusInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H5N2 SubtypeNeuraminidaseOrthomyxoviridae InfectionsReceptors, Cell SurfaceReceptors, VirusRespiratory MucosaVirus AttachmentNeuraminidaseReceptors, Cell SurfaceReceptors, Virussialic acid receptor

Identifiers

PMID28386114
PMCPMC5429623
OpenAlexW2603253541

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.