Evidence map›Paper›PMID 28386104›Full record

ArticleScientific reports2017

Intubation-free in vivo imaging of the tracheal mucosa using two-photon microscopy.

Tibor Z Veres, Tamás Kopcsányi, Marko Tirri, Armin Braun, Masayuki Miyasaka, Ronald N Germain, Sirpa Jalkanen, Marko Salmi

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Two-Photon Intravital Microscopy of Glioblastoma in a Murine Model.Journal of visualized experiments : JoVE · 2024
    Article
  4. Review
  5. PCD Genes-From Patients to Model Organisms and Back to Humans.International journal of molecular sciences · 2022
    Review
  6. Article
  7. Article
  8. Motile cilia genetics and cell biology: big results from little mice.Cellular and molecular life sciences : CMLS · 2021
    Review
  9. Review
  10. Review
  11. Tracing Antiviral CD8Journal of immunology (Baltimore, Md. : 1950) · 2019
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 5 countries.

Tibor Z VeresMediCity Research Laboratory, University of Turku, Turku, 20520, Finland. tibor.veres@utu.fi.ORCID http://orcid.org/0000-0002-6980-8900
Tamás KopcsányiMediCity Research Laboratory, University of Turku, Turku, 20520, Finland.
Marko TirriInstitute of Biomedicine, Turku Center for Disease Modeling, and Turku PET Centre, University of Turku, Turku, 20520, Finland.
Armin BraunDepartment of Preclinical Pharmacology and In Vitro Toxicology, Fraunhofer Institute for Toxicology and Experimental Medicine, and Institute of Immunology, MHH; Hannover, 30625 Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Centre for Lung Research (DZL), Hannover, Germany.
Masayuki MiyasakaMediCity Research Laboratory, University of Turku, Turku, 20520, Finland.ORCID http://orcid.org/0000-0001-6122-5201
Ronald N GermainLymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Sirpa JalkanenMediCity Research Laboratory, University of Turku, Turku, 20520, Finland.
Marko SalmiMediCity Research Laboratory, University of Turku, Turku, 20520, Finland.
University of Turku · FIFraunhofer Institute for Toxicology and Experimental Medicine · DENational Institutes of Health · US

Funding

Multiscale Analysis of Immune ResponsesZIAAI000545 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2025
$29.4M
Functional Biology Of T CellsZIAAI000758 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2025
$15.4M
6 · The paper itself

Abstract

The mucosal layer of conducting airways is the primary tissue exposed to inhaled microorganisms, allergens and pollutants. We developed an in vivo two-photon microscopic approach that allows performing dynamic imaging studies in the mouse trachea, which is a commonly used in vivo model of human small-diameter bronchi. By providing stabilized access to the tracheal mucosa without intubation, our setup uniquely allows dynamic in vivo imaging of mucociliary clearance and steady-state immune cell behavior within the complex airway mucosal tissue.

Indexed as

Intravital MicroscopyMicroscopy, Fluorescence, MultiphotonAnimalsCiliaHumansImage Processing, Computer-AssistedMiceMucociliary ClearanceRespiratory MucosaTracheaX-Ray Microtomography

Identifiers

PMID28386104
PMCPMC5429620
OpenAlexW2603284807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.