ArticleScientific reports2017
Higher dietary intakes of choline and betaine are associated with a lower risk of primary liver cancer: a case-control study.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Gut microbiome modulates the outcome in primary central nervous system lymphoma patients undergoing chemotherapy: An ancillary study from the BLOCAGE trial.Neuro-oncology · 2025Trial
- Betaine alleviates hepatic lipid metabolism disorder in finishing pigs fed a low-energy diet through regulating mJournal of animal science and biotechnology · 2025Article
- Effect of light-emitting diode photobiomodulation on rat liver metabolomics after streptozotocin-induced diabetes - an evidence from nuclear magnetic resonance spectroscopy.Lasers in medical science · 2025Article
- Low Glycemic Index Biscuits Enriched with Beetroot Powder as a Source of Betaine and Mineral Nutrients.Foods (Basel, Switzerland) · 2025Article
- Betaine inhibits the stem cell-like properties of hepatocellular carcinoma by activating autophagy via SAM/mTheranostics · 2025Article
- The association of serum choline concentrations with the risk of cancers: a community-based nested case-control study.Scientific reports · 2023Article
- Dietary Choline and Betaine Intake and Risk of Colorectal Cancer in an Iranian Population.Cancers · 2023Article
- Article
- Integrative functional analysis uncovers metabolic differences between Candida species.Communications biology · 2022Article
- Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance.Nature communications · 2022Article
- Liver Lipids of Patients with Hepatitis B and C and Associated Hepatocellular Carcinoma.International journal of molecular sciences · 2021Article
- Betaine inhibits Toll-like receptor 4 responses and restores intestinal microbiota in acute liver failure mice.Scientific reports · 2020Article
- One-carbon metabolism-related micronutrients intake and risk for hepatocellular carcinoma: A prospective cohort study.International journal of cancer · 2020Article
- Conventional and Unconventional Therapeutic Strategies for Sialidosis Type I.Journal of clinical medicine · 2020Article
- Protein kinase C promotes choline transporter‑like protein 1 function via improved cell surface expression in immortalized human hepatic cells.Molecular medicine reports · 2020Article
- Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study.Nutrition & metabolism · 2020Article
- Betaine suppresses cell proliferation by increasing oxidative stress-mediated apoptosis and inflammation in DU-145 human prostate cancer cell line.Cell stress & chaperones · 2019Article
- Review
- Identification of the Potential Metabolic Pathways Involved in the Hepatic Tumorigenesis of Rat Diethylnitrosamine-Induced Hepatocellular Carcinoma viaBioMed research international · 2019Article
- Dietary Additives and Supplements Revisited: The Fewer, the Safer for Liver and Gut Health.Current pharmacology reports · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dietary intake of methyl donors is favorably associated with many diseases, but the findings regarding primary liver cancer (PLC) risk are limited. This study investigated the association between the intake of choline, betaine and methionine and PLC risk in adults. This 1:1 matched case-control study enrolled 644 hospital-based PLC patients and 644 community-based controls who were matched by sex and age, in Guangzhou, China. An interviewer-administered questionnaire and a food-frequency questionnaire were used to collect general information and dietary intake information. Conditional logistic regression showed a significantly inverse association between total choline and betaine intakes and PLC risk. The multivariable-adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) for PLC for the top (vs. bottom) tertile were 0.34 (0.24-0.49; P
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