Evidence map›Paper›PMID 28386022›Full record

ArticleJournal of cell science2017

Multiple roles of integrin-α3 at the neuromuscular junction.

Jacob A Ross, Richard G Webster, Tanguy Lechertier, Louise E Reynolds, Mark Turmaine, Maximilien Bencze, Yalda Jamshidi, Hakan Cetin, Francesco Muntoni, David Beeson and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Jacob A RossDubowitz Neuromuscular Centre, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.
Richard G WebsterNuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
Tanguy LechertierCentre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Louise E ReynoldsCentre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Mark TurmaineDepartment of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
Maximilien BenczeDubowitz Neuromuscular Centre, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.
Yalda JamshidiDepartment of Genetics, Institute of Molecular and Clinical Sciences, St George's University of London, Cranmer Terrace, London SW17 0RE, UK.
Hakan CetinNuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
Francesco MuntoniDubowitz Neuromuscular Centre, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.
David BeesonNuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
Kairbaan Hodilvala-DilkeCentre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Francesco J ContiDubowitz Neuromuscular Centre, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK f.conti@ucl.ac.uk.ORCID 0000-0002-9887-7323
University College London · GBJohn Radcliffe Hospital · GBQueen Mary University of London · GBSt George's, University of London · GB

Funding

Cancer Research UKMedical Research Council MR/M006824/1
6 · The paper itself

Abstract

The neuromuscular junction (NMJ) is the synapse between motoneurons and skeletal muscle, and is responsible for eliciting muscle contraction. Neurotransmission at synapses depends on the release of synaptic vesicles at sites called active zones (AZs). Various proteins of the extracellular matrix are crucial for NMJ development; however, little is known about the identity and functions of the receptors that mediate their effects. Using genetically modified mice, we find that integrin-α3 (encoded by

Indexed as

AgingAnimalsAutophagyCalciumEmbryonic DevelopmentIntegrin alpha3Mice, Inbred C57BLMotor NeuronsMuscle DevelopmentMuscle Fibers, SkeletalMutationNeuromuscular JunctionProtein TransportSynapsesSynaptic TransmissionSynaptic VesiclesCalciumIntegrin alpha3Adhesion receptorAgeingAutophagyNeurodegenerationSynapse

Identifiers

PMID28386022
PMCPMC5450193
OpenAlexW2605153756

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.