Evidence map›Paper›PMID 28385888›Full record

ArticleThe Journal of biological chemistry2017

Modeling and high-throughput experimental data uncover the mechanisms underlying

Estee Stern, Frederique Ruf-Zamojski, Lisa Zalepa-King, Hanna Pincas, Soon Gang Choi, Charles S Peskin, Fernand Hayot, Judith L Turgeon, Stuart C Sealfon

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Mathematical Modelling of Endocrine Systems.Trends in endocrinology and metabolism: TEM · 2019
    Review
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Estee SternFrom the Department of Neurology and.
Frederique Ruf-ZamojskiFrom the Department of Neurology and.
Lisa Zalepa-KingFrom the Department of Neurology and.
Hanna PincasFrom the Department of Neurology and.
Soon Gang ChoiFrom the Department of Neurology and.
Charles S Peskinthe Courant Institute of Mathematical Sciences and Center for Neural Science, New York University, New York, New York 10012, and.
Fernand HayotFrom the Department of Neurology and.
Judith L Turgeonthe Division of Endocrinology, Department of Internal Medicine, School of Medicine, University of California, Davis, California 95616.
Stuart C SealfonFrom the Department of Neurology and stuart.sealfon@mssm.edu.ORCID 0000-0001-5791-1217
New York University · USCourant Institute of Mathematical Sciences · USDSM (Netherlands) · NLUniversity of California, Davis · US

Funding

MOLECULAR MECHANISM OF AGONISM AT THE GNRH RECEPTORR01DK046943 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI STUART C. SEALFON · 1993 to 2026
$11.0M
Integrated systems biology of the pituitaryR56DK046943 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SEALFON, STUART C. · 2006 to 2024
$555k
NIDDK NIH HHS R01 DK046943NIDDK NIH HHS R56 DK046943
6 · The paper itself

Abstract

Neuroendocrine control of reproduction by brain-secreted pulses of gonadotropin-releasing hormone (GnRH) represents a longstanding puzzle about extracellular signal decoding mechanisms. GnRH regulates the pituitary gonadotropin's follicle-stimulating hormone (FSH) and luteinizing hormone (LH), both of which are heterodimers specified by unique β subunits (FSHβ/LHβ). Contrary to

Indexed as

Computer SimulationEarly Growth Response Protein 1Follicle Stimulating Hormone, beta SubunitGene Expression RegulationGonadotropin-Releasing HormoneHumansLuteinizing Hormone, beta SubunitModels, BiologicalProto-Oncogene Proteins c-fosEarly Growth Response Protein 1EGR1 protein, humanFollicle Stimulating Hormone, beta SubunitGonadotropin-Releasing HormoneLuteinizing Hormone, beta SubunitProto-Oncogene Proteins c-fosaverage GnRH concentrationfollicle-stimulating hormone (FSH)gene expressiongene regulationGnRH pulse frequencygonadotropeG proteinmathematical modeling

Identifiers

PMID28385888
PMCPMC5465502
OpenAlexW2604986703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.