ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2017
Failure of fertility therapy and subsequent adverse cardiovascular events.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Association between multiple pregnancy with peripartum cardiomyopathy: a systematic review and meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Association of infertility treatments and incidence of stroke among women: a systematic review.Reproduction & fertility · 2025Pooled it
- Persistent organic pollutants and couple fecundability: a systematic review.Human reproduction update · 2021Pooled it
- Long-term risk of cardiovascular disease after assisted reproductive technology and infertility: A cohort study.PLoS medicine · 2026Article
- Assisted Reproductive Technology and Cardiovascular Outcomes in Women: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Menopause Hormone Therapy in Women With Cardiovascular Risk Factors or Established Ischemic Heart Disease: A Joint FIGO and WHF Position Paper.Global heart · 2026Review
- A Review of Traditional and Non-Traditional Cardiovascular Risk Factors in Women.International journal of women's health · 2026Review
- Cardiovascular contributions to dementia: Examining sex differences and female-specific factors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Fertility treatments and stroke: a scoping review.BMJ open · 2025Article
- Review
- The association between the triglyceride-glucose index with all-cause and cardiovascular mortality within the infertility population.PloS one · 2025Article
- Atrial fibrillation considerations in the fourth trimester (postpartum period).Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Review
- Review
- Primary Prevention of Cardiovascular Disease in Women.Methodist DeBakey cardiovascular journal · 2024Review
- Dietary Strategies to Reduce Triglycerides in Women of Reproductive Age: A Simulation Modelling Study.Nutrients · 2023Article
- Defining preventive cardiology: A clinical practice statement from the American Society for Preventive Cardiology.American journal of preventive cardiology · 2022Review
- Atherosclerotic cardiovascular disease risk assessment: An American Society for Preventive Cardiology clinical practice statement.American journal of preventive cardiology · 2022Article
- Protective placental inflammatory and oxidative stress responses are attenuated in the context of twin pregnancy and chorioamnionitis in assisted reproduction.Journal of assisted reproduction and genetics · 2022Article
- Assisted Reproductive Technology Outcomes in Women With Heart Disease.Frontiers in cardiovascular medicine · 2022Article
- Maternal cardiovascular disease after twin pregnancies complicated by hypertensive disorders of pregnancy: a population-based cohort study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfertility may indicate an underlying predisposition toward premature cardiovascular disease, yet little is known about potential long-term cardiovascular events following fertility therapy. We investigated whether failure of fertility therapy is associated with subsequent adverse cardiovascular events.
methodsWe performed a population-based cohort analysis of women who received gonadotropin-based fertility therapy between Apr. 1, 1993, and Mar. 31, 2011, distinguishing those who subsequently gave birth and those who did not. Using multivariable Poisson regression models, we estimated the relative rate ratio of adverse cardiovascular events associated with fertility therapy failure, accounting for age, year, baseline risk factors, health care history and number of fertility cycles. The primary outcome was subsequent treatment for nonfatal coronary ischemia, stroke, transient ischemic attack, heart failure or thromboembolism.
resultsOf 28 442 women who received fertility therapy, 9349 (32.9%) subsequently gave birth and 19 093 (67.1%) did not. The median number of fertility treatments was 3 (interquartile range 1-5). We identified 2686 cardiovascular events over a median 8.4 years of follow-up. The annual rate of cardiovascular events was 19% higher among women who did not give birth after fertility therapy than among those who did (1.08 v. 0.91 per 100 patient-years,
interpretationFertility therapy failure was associated with an increased risk of long-term adverse cardiovascular events. These women merit surveillance for subsequent cardiovascular events.
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Registered trials
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