Evidence map›Paper›PMID 28385814›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2017

TNFα enhances force generation in airway smooth muscle.

Murat Dogan, Young-Soo Han, Philippe Delmotte, Gary C Sieck

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Molecular mechanisms underlying FCCP-induced mitophagy in human airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  3. Review
  4. Tumor necrosis factor α-induced endoplasmic reticulum stress promotes airway smooth muscle cell proliferation.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  5. Review
  6. TNFα-mediated subcellular heterogeneity of succinate dehydrogenase activity in human airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  7. Review
  8. Multifaceted roles of mitochondria in asthma.Cell biology and toxicology · 2024
    Review
  9. Article
  10. Molecular mechanisms underlying TNFα-induced mitochondrial fragmentation in human airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Airway remodeling in asthma.Annals of translational medicine · 2022
    Article
  15. Article
  16. Dynamic cytosolic CaAmerican journal of physiology. Lung cellular and molecular physiology · 2021
    Article
  17. TNFα induces mitochondrial fragmentation and biogenesis in human airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2021
    Article
  18. Effects of TNFα on Dynamic Cytosolic CaFrontiers in physiology · 2021
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Murat DoganDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0003-0002-8428
Young-Soo HanDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Philippe DelmotteDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Gary C SieckDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota sieck.gary@mayo.edu.
Mayo Clinic · US

Funding

Calcium Regulation in Airway Smooth MuscleR01HL074309 · NHLBI · MAYO CLINIC ROCHESTER · PI SIECK, GARY C. · 2005 to 2013
$3.3M
Role of Mitochondria in Airway Smooth MuscleR01HL126451 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S., SIECK, GARY C. · 2015 to 2018
$1.9M
NHLBI NIH HHS R01 HL074309NHLBI NIH HHS R01 HL126451
6 · The paper itself

Abstract

Airway inflammation is a hallmark of asthma, triggering airway smooth muscle (ASM) hyperreactivity and airway remodeling. TNFα increases both agonist-induced cytosolic Ca

Indexed as

ActinsAdenosine TriphosphateAnimalsBiomechanical PhenomenaCalciumHydrolysisIsometric ContractionMuscle, SmoothMyosin Heavy ChainsMyosin Light ChainsPermeabilityPhosphorylationPolymerizationSus scrofaTumor Necrosis Factor-alphaActinsAdenosine TriphosphateCalciumMyosin Heavy ChainsMyosin Light ChainsTumor Necrosis Factor-alphaactin polymerizationasthmaATP hydrolysis ratemyosin heavy chainmyosin light chain

Identifiers

PMID28385814
PMCPMC5495949
OpenAlexW2604229352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.