Evidence map›Paper›PMID 28385813›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2017

Acidosis increases the susceptibility of respiratory epithelial cells to

Iviana M Torres, Sally Demirdjian, Jennifer Vargas, Britton C Goodale, Brent Berwin

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Autonomous Polymer Frameworks for Sustainable Tissue-Interfaced Plastic Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  5. Article
  6. Inhibition of proton sensor GPR68 suppresses endothelial dysfunction and acute lung injury caused by Staphylococcus aureus bacterial particles.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  7. Immunization with lytic polysaccharide monooxygenase CbpD induces protective immunity againstProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Optimizing tylosin dosage for co-infection ofFrontiers in pharmacology · 2023
    Article
  9. Article
  10. Role of Host and Bacterial Lipids inFrontiers in immunology · 2022
    Review
  11. Review
  12. Article
  13. Article
  14. International journal of molecular sciences · 2020
    Review
  15. Acidosis induces antimicrobial peptide expression and resistance to uropathogenicAmerican journal of physiology. Renal physiology · 2020
    Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Iviana M TorresDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
Sally DemirdjianDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
Jennifer VargasDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
Britton C GoodaleDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
Brent BerwinDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire brent.berwin@dartmouth.edu.
Dartmouth College · US

Funding

IMMUNOBIOLOGY OF MYELOID AND LYMPHOID CELLST32AI007363 · NIAID · DARTMOUTH COLLEGE · PI Claudia V Jakubzick · 1990 to 2026
$9.5M
TRANSLATIONAL RESEARCH COREP30GM106394 · NIGMS · DARTMOUTH COLLEGE · PI STANTON, BRUCE A. · 2013 to 2017
$6.1M
Role of Virulence Factors in Pseudomonas-Host InteractionsR01HL074175 · NHLBI · DARTMOUTH COLLEGE · PI STANTON, BRUCE A. · 2003 to 2018
$5.0M
Type III effector-cofactor dynamics within the cellular environmentR01AI104922 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI FEIX, JIMMY, FRANK, DARA W. · 2013 to 2021
$3.7M
CENTER FOR MOLECULAR, CELLULAR, AND TRANSLATIONAL IMMUNOLOGYP30RR032136 · NCRR · DARTMOUTH COLLEGE · PI GREEN, WILLIAM R · 2011 to 2011
$1.2M
The Role of Flagellar Motility to Innate Immune Recognition of BacteriaR21AI121820 · NIAID · DARTMOUTH COLLEGE · PI BERWIN, BRENT L · 2016 to 2017
$461k
Low-dose arsenic impacts innate immune response in bronchial epithelial cellsF32ES025082 · NIEHS · DARTMOUTH COLLEGE · PI GOODALE, BRITTON C · 2015 to 2017
$168k
NCRR NIH HHS P30 RR032136NHLBI NIH HHS R01 HL074175NIAID NIH HHS R01 AI104922NIAID NIH HHS R21 AI121820NIAID NIH HHS T32 AI007363NIEHS NIH HHS F32 ES025082NIGMS NIH HHS P30 GM106394
6 · The paper itself

Abstract

Bacterial infection can lead to acidosis of the local microenvironment, which is believed to exacerbate disease pathogenesis; however, the mechanisms by which changes in pH alter disease progression are poorly understood. We test the hypothesis that acidosis enhances respiratory epithelial cell death in response to infection with

Indexed as

A549 CellsAcidosisAntimicrobial Cationic PeptidesBacterial ProteinsCell DeathEpithelial CellsHumansHydrogen-Ion ConcentrationLungMicrobial ViabilityPseudomonas aeruginosaPseudomonas InfectionsAntimicrobial Cationic PeptidesBacterial Proteinsacidosiscell deathepithelial cellsPseudomonas aeruginosa

Identifiers

PMID28385813
PMCPMC5538871
OpenAlexW2604583184

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.