Evidence map›Paper›PMID 28385807›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2017

Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca

Dheeraj Soni, Sushil C Regmi, Dong-Mei Wang, Auditi DebRoy, You-Yang Zhao, Stephen M Vogel, Asrar B Malik, Chinnaswamy Tiruppathi

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Microvascular Health as a Key Determinant of Organismal Aging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  3. Molecular Mechanisms Regulating Vascular Endothelial Permeability.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. IPCellular and molecular life sciences : CMLS · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dheeraj SoniDepartment of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, Illinois.
Sushil C RegmiDepartment of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, Illinois.
Dong-Mei WangDepartment of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, Illinois.
Auditi DebRoyDepartment of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, Illinois.
You-Yang ZhaoDepartment of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, Illinois.
Stephen M VogelDepartment of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, Illinois.
Asrar B MalikDepartment of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, Illinois.
Chinnaswamy TiruppathiDepartment of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, Illinois tiruc@uic.edu.
University of Illinois Urbana-Champaign · USUniversity of Illinois Chicago · US

Funding

TRPC6 Regulation of Lung Endothelial Barrier FunctionP01HL060678 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MALIK, ASRAR B. · 2000 to 2020
$40.1M
Trpm2 Regulation of Phagocyte Bactericidal Activity and Resolution of Lung InjuryP01HL077806 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ZHAO, YOU-YANG · 2005 to 2019
$27.0M
THROMBIN-INDUCED PULMONARY VASCULAR PERMEABILITYR01HL045638 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KOMAROVA, YULIA A · 1991 to 2025
$12.0M
Novel mechanisms of obliterative pulmonary vascular remodeling and sever pulmonary arterial hypertensionR01HL133951 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ZHAO, YOU-YANG · 2016 to 2024
$4.9M
Repair mechanisms of sepsis induced endothelial dysfunction and lung injuryR01HL125350 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MALIK, ASRAR B., ZHAO, YOU-YANG · 2014 to 2018
$3.2M
Novel Signalings and Molecular Targets Of Endothelial Regeneration In Aging LungR01HL123957 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ZHAO, YOU-YANG · 2014 to 2018
$2.0M
Endothelial Cell Deubiquitinase A20 Signals Repair of Lung Vascular InjuryR01HL128359 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TIRUPPATHI, CHINNASWAMY · 2015 to 2018
$1.6M
TRPM2 mediates neutrophil transendothelial migration and inflammationR01HL122157 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TIRUPPATHI, CHINNASWAMY · 2015 to 2018
$1.6M
Endothelial TAK1 Signaling and Resolution of Pulmonary Edema in SepsisR01GM117028 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TIRUPPATHI, CHINNASWAMY · 2016 to 2019
$1.3M
NHLBI NIH HHS P01 HL060678NHLBI NIH HHS P01 HL077806NHLBI NIH HHS R01 HL045638NHLBI NIH HHS R01 HL122157NHLBI NIH HHS R01 HL125350NHLBI NIH HHS R01 HL128359NHLBI NIH HHS R01 HL133951NIGMS NIH HHS R01 GM117028
6 · The paper itself

Abstract

Vascular endothelial protein tyrosine phosphatase (VE-PTP) stabilizes endothelial adherens junctions (AJs) through constitutive dephosphorylation of VE-cadherin. Here we investigated the role of stromal interaction molecule 1 (STIM1) activation of store-operated Ca

Indexed as

Adherens JunctionsAnimalsAntigens, CDCadherin 5CadherinsCalciumCapillary PermeabilityCell Membrane PermeabilityEndothelial CellsEnzyme ActivationFocal Adhesion Kinase 2Gene Knockdown TechniquesGene SilencingHumansMice, Inbred C57BLMicrovesselsAntigens, CDCadherin 5CadherinsCalciumFocal Adhesion Kinase 2Neoplasm ProteinsPeptidesPhosphotyrosineReceptor-Like Protein Tyrosine Phosphatases, Class 3Receptor, PAR-1src-Family KinasesSTIM1 protein, humanStim1 protein, mouseStromal Interaction Molecule 1permeability increasePyk2store-operated Ca2+ entrystromal interaction molecule 1thrombinvascular endothelial protein tyrosine phosphataseVE-cadherin

Identifiers

PMID28385807
PMCPMC5495943
OpenAlexW2604610642

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.