Evidence map›Paper›PMID 28385796›Full record

ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2017

Harnessing Preclinical Molecular Imaging to Inform Advances in Personalized Cancer Medicine.

Peter M Clark, Victoria A Ebiana, Laura Gosa, Timothy F Cloughesy, David A Nathanson

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018
    Article
  6. Noninvasive Imaging of Drug-Induced Liver Injury withJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018
    Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Peter M ClarkDepartment of Molecular and Medical Pharmacology, David Geffen UCLA School of Medicine, Los Angeles, California.
Victoria A EbianaDepartment of Neurology, David Geffen UCLA School of Medicine, Los Angeles, California; and.
Laura GosaDepartment of Molecular and Medical Pharmacology, David Geffen UCLA School of Medicine, Los Angeles, California.
Timothy F CloughesyDepartment of Neurology, David Geffen UCLA School of Medicine, Los Angeles, California; and.
David A NathansonDepartment of Molecular and Medical Pharmacology, David Geffen UCLA School of Medicine, Los Angeles, California dnathanson@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Targeting metabolic vulnerabilities in glioblastomaR01CA213133 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NATHANSON, DAVID A. · 2017 to 2021
$2.5M
NCI NIH HHS R01 CA213133
6 · The paper itself

Abstract

Comprehensive molecular analysis of individual tumors provides great potential for personalized cancer therapy. However, the presence of a particular genetic alteration is often insufficient to predict therapeutic efficacy. Drugs with distinct mechanisms of action can affect the biology of tumors in specific and unique ways. Therefore, assays that can measure drug-induced perturbations of defined functional tumor properties can be highly complementary to genomic analysis. PET provides the capacity to noninvasively measure the dynamics of various tumor biologic processes in vivo. Here, we review the underlying biochemical and biologic basis for a variety of PET tracers and how they may be used to better optimize cancer therapy.

Indexed as

AnimalsBiomarkers, TumorDrug Evaluation, PreclinicalEarly Detection of CancerHumansMolecular ImagingNeoplasms, ExperimentalPositron-Emission TomographyPrecision MedicineTranslational Research, BiomedicalBiomarkers, Tumorearly response biomarkerspersonalized cancer therapyPET imaging tracerspharmacodynamic imagingprecision medicine

Identifiers

PMID28385796
PMCPMC12079153
OpenAlexW2604938263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.