Evidence map›Paper›PMID 28385702›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2017

A Shift in ApoM/S1P Between HDL-Particles in Women With Type 1 Diabetes Mellitus Is Associated With Impaired Anti-Inflammatory Effects of the ApoM/S1P Complex.

Cecilia Frej, Armando J Mendez, Mario Ruiz, Melanie Castillo, Thomas A Hughes, Björn Dahlbäck, Ronald B Goldberg

Abstract read
PubMed Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 61 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. HDL metabolism and function in diabetes mellitus.Nature reviews. Endocrinology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Apolipoprotein M gene polymorphisms in childhood-onset type 1 diabetes in southern Brazil.International journal of biochemistry and molecular biology · 2023
    Article
  13. Review
  14. Article
  15. Review
  16. The FoxOs are in the ApoM house.The Journal of clinical investigation · 2022
    Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Cecilia FrejFrom the Division of Clinical Chemistry, Department of Translational Medicine, Lund University, Malmö, Sweden (C.F., M.R., B.D.); Health Science Center, Department of Medicine, University of Tennessee, Memphis (T.A.H.); and Division of Endocrinology, Metabolism and Diabetes and Diabetes Research Institute, University of Miami Miller School of Medicine, FL (A.J.M., M.C., R.B.G.).
Armando J MendezFrom the Division of Clinical Chemistry, Department of Translational Medicine, Lund University, Malmö, Sweden (C.F., M.R., B.D.); Health Science Center, Department of Medicine, University of Tennessee, Memphis (T.A.H.); and Division of Endocrinology, Metabolism and Diabetes and Diabetes Research Institute, University of Miami Miller School of Medicine, FL (A.J.M., M.C., R.B.G.).
Mario RuizFrom the Division of Clinical Chemistry, Department of Translational Medicine, Lund University, Malmö, Sweden (C.F., M.R., B.D.); Health Science Center, Department of Medicine, University of Tennessee, Memphis (T.A.H.); and Division of Endocrinology, Metabolism and Diabetes and Diabetes Research Institute, University of Miami Miller School of Medicine, FL (A.J.M., M.C., R.B.G.).
Melanie CastilloFrom the Division of Clinical Chemistry, Department of Translational Medicine, Lund University, Malmö, Sweden (C.F., M.R., B.D.); Health Science Center, Department of Medicine, University of Tennessee, Memphis (T.A.H.); and Division of Endocrinology, Metabolism and Diabetes and Diabetes Research Institute, University of Miami Miller School of Medicine, FL (A.J.M., M.C., R.B.G.).
Thomas A HughesFrom the Division of Clinical Chemistry, Department of Translational Medicine, Lund University, Malmö, Sweden (C.F., M.R., B.D.); Health Science Center, Department of Medicine, University of Tennessee, Memphis (T.A.H.); and Division of Endocrinology, Metabolism and Diabetes and Diabetes Research Institute, University of Miami Miller School of Medicine, FL (A.J.M., M.C., R.B.G.).
Björn DahlbäckFrom the Division of Clinical Chemistry, Department of Translational Medicine, Lund University, Malmö, Sweden (C.F., M.R., B.D.); Health Science Center, Department of Medicine, University of Tennessee, Memphis (T.A.H.); and Division of Endocrinology, Metabolism and Diabetes and Diabetes Research Institute, University of Miami Miller School of Medicine, FL (A.J.M., M.C., R.B.G.). RGoldber@med.miami.edu bjorn.dahlback@med.lu.se.
Ronald B GoldbergFrom the Division of Clinical Chemistry, Department of Translational Medicine, Lund University, Malmö, Sweden (C.F., M.R., B.D.); Health Science Center, Department of Medicine, University of Tennessee, Memphis (T.A.H.); and Division of Endocrinology, Metabolism and Diabetes and Diabetes Research Institute, University of Miami Miller School of Medicine, FL (A.J.M., M.C., R.B.G.). RGoldber@med.miami.edu bjorn.dahlback@med.lu.se.
University of Tennessee Health Science Center · US

Funding

Biomarkers and Outcomes in the Diabetes Prevention ProgramR01DK078907 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GOLDBERG, RONALD B · 2008 to 2010
$1.5M
NIDDK NIH HHS R01 DK078907
6 · The paper itself

Abstract

objectiveType 1 diabetes mellitus (T1D) patients have an increased risk of cardiovascular disease despite high levels of high-density lipoproteins (HDL). Apolipoprotein M (apoM) and its ligand sphingosine 1-phospate (S1P) exert many of the anti-inflammatory effects of HDL. We investigated whether apoM and S1P are altered in T1D and whether apoM and S1P are important for HDL functionality in T1D. APPROACH AND

resultsApoM and S1P were quantified in plasma from 42 healthy controls and 89 T1D patients. HDL was isolated from plasma and separated into dense, medium-dense, and light HDL by ultracentrifugation. Primary human aortic endothelial cells were challenged with tumor necrosis factor-α in the presence or absence of isolated HDL. Proinflammatory adhesion molecules E-selectin and vascular cellular adhesion molecule-1 were quantified by flow cytometry. Activation of the S1P

conclusionsApoM/S1P in light HDL particles were inefficient in inhibiting tumor necrosis factor-α-induced vascular cellular adhesion molecule-1 expression in contrast to apoM/S1P in denser HDL particles. T1D patients have a higher proportion of light particles and hence more dysfunctional HDL, which could contribute to the increased cardiovascular disease risk associated with T1D.

Indexed as

AdultApolipoproteinsApolipoproteins MBiomarkersCase-Control StudiesCells, CulturedChromatography, LiquidDiabetes Mellitus, Type 1EndocytosisEndothelial CellsEnzyme ActivationEnzyme-Linked Immunosorbent AssayE-SelectinExtracellular Signal-Regulated MAP KinasesFemaleHumansApolipoproteinsApolipoproteins MAPOM protein, humanBiomarkersE-SelectinExtracellular Signal-Regulated MAP KinasesLipocalinsLipoproteins, HDLLysophospholipidsReceptors, LysosphingolipidS1PR1 protein, humanSELE protein, humanSphingosinesphingosine 1-phosphateSphingosine-1-Phosphate ReceptorsTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1apolipoproteinsendotheliumlipoproteinssphingolipidstumor necrosis factor-alpha

Identifiers

PMID28385702
OpenAlexW2605141246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.