ArticleNeurobiology of aging2017
Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan.
Article in Neurobiology of aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- HIF-1 Targeting Intervention Renders Protection From Alzheimer's-Like Pathology in a Humanized Mice Model of HIV Infection.Journal of extracellular vesicles · 2025Article
- Reviewing the possible connection between cerebral amyloid angiopathy and blood-brain barrier integrity in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Aβ and tau prions feature in the neuropathogenesis of Down syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cell models for Down syndrome-Alzheimer's disease research.Neuronal signaling · 2022Review
- Blood Biomarkers for Alzheimer's Disease in Down Syndrome.Journal of clinical medicine · 2021Review
- High-resolution functional connectivity of the default mode network in young adults with down syndrome.Brain imaging and behavior · 2021Article
- Postmortem NeocorticalFrontiers in aging neuroscience · 2021Article
- Altered connectivity of the default mode network in cognitively stable adults with Down syndrome: "Accelerated aging" or a prelude to Alzheimer's disease?Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Regional binding of tau and amyloid PET tracers in Down syndrome autopsy brain tissue.Molecular neurodegeneration · 2020Article
- Alzheimer's disease: from basic science to precision medicine approach.BMJ neurology open · 2020Review
- Brain amyloid and the transition to dementia in Down syndrome.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Neuropathological correlates of amyloid PET imaging in Down syndrome.Developmental neurobiology · 2019Review
- Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia.Acta neuropathologica · 2019Article
- "Donating our bodies to science": A discussion about autopsy and organ donation in Turner syndrome.American journal of medical genetics. Part C, Seminars in medical genetics · 2019Review
- Down syndrome, beta-amyloid and neuroimaging.Free radical biology & medicine · 2018Review
- Neuroimaging and other modalities to assess Alzheimer's disease in Down syndrome.NeuroImage. Clinical · 2018Review
- Metabolic and Vascular Imaging Biomarkers in Down Syndrome Provide Unique Insights Into Brain Aging and Alzheimer Disease Pathogenesis.Frontiers in aging neuroscience · 2018Review
- A Review of Functional Neuroimaging in People with Down Syndrome with and without Dementia.Dementia and geriatric cognitive disorders extraReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Beta-amyloid (Aβ) deposition in brain accumulates as a function of age in people with Down syndrome (DS) with subsequent development into Alzheimer disease neuropathology, typically by 40 years of age. In vivo imaging using the Pittsburgh compound B (PiB) ligand has facilitated studies linking Aβ, cognition, and dementia in DS. However, there are no studies of PiB binding across the lifespan in DS. The current study describes in vitro
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.