ArticleOsteoarthritis and cartilage2017
Analgesic use and risk of recurrent falls in participants with or at risk of knee osteoarthritis: data from the Osteoarthritis Initiative.
Article in Osteoarthritis and cartilage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 55 citations in OpenAlex.
- Mechanistic Pathways Linking Type 2 Diabetes Mellitus, Hypertension, and Osteoarthritis to Falls in Older Adults: A Scoping Review.Healthcare (Basel, Switzerland) · 2026Review
- Machine learning-based prediction model for fall risk among individuals with arthritis in China: an analysis using the China Health and Retirement Longitudinal Study (CHARLS) database.Journal of health, population, and nutrition · 2026Article
- The association between anserine bursa pain and fall susceptibility: a prospective analysis of the osteoarthritis initiative.Frontiers in aging · 2025Article
- Patterns of analgesic utilisation among people with knee osteoarthritis: a cohort study using UK primary care data.Journal of pharmaceutical policy and practice · 2025Article
- Anterior knee pain as a potential risk factor for falls in older adults: insights from the osteoarthritis initiative data.BMC public health · 2023Observational
- The Association Between Severity of Radiographic Knee OA and Recurrent Falls in Middle and Older Aged Adults: The Osteoarthritis Initiative.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Article
- Wearable transcutaneous electrical nerve stimulation (actiTENS®) is effective and safe for the treatment of knee osteoarthritis pain: a randomized controlled trialTherapeutic advances in musculoskeletal disease · 2022Article
- Current use of analgesics and the risk of falls in people with knee osteoarthritis: A population-based cohort study using primary care and hospital records.Osteoarthritis and cartilage open · 2021Article
- Opioid users show worse baseline knee osteoarthritis and faster progression of degenerative changes: a retrospective case-control study based on data from the Osteoarthritis Initiative (OAI).Arthritis research & therapy · 2021Article
- Analysis of the Associations between Arthritis and Fall Histories in Korean Adults.International journal of environmental research and public health · 2021Article
- Opioid prescriptions in patients with osteoarthritis: a population-based cohort study.Rheumatology (Oxford, England) · 2020Article
- Clinical osteoarthritis of the hip and knee and fall risk: The role of low physical functioning and pain medication.Seminars in arthritis and rheumatism · 2020Article
- Multimorbidity and Opioid Prescribing in Hospitalized Older Adults.Journal of palliative medicine · 2020Article
- Task-Specific Perturbation Training Improves the Recovery Stepping Responses by Women With Knee Osteoarthritis Following Laboratory-Induced Trips.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveFew studies have compared the risk of recurrent falls across different types of analgesic use, and with limited adjustment for potential confounders (e.g., pain/depression severity). We assessed analgesic use and the subsequent risk of recurrent falls, among participants with or at risk of knee osteoarthritis (OA).
methodsA longitudinal analysis included 4231 participants aged 45-79 years at baseline with 4-year follow-up from the Osteoarthritis Initiative (OAI) cohort study. We grouped participants into six mutually exclusive subgroups based on annually assessed analgesic use in the following hierarchical order of analgesic/central nervous system (CNS) potency: use of (1) opioids, (2) antidepressants, (3) other prescription pain medications, (4) over-the-counter (OTC) pain medications, (5) nutraceuticals, and (6) no analgesics. We used multivariable modified Poisson regression models with a robust error variance to estimate the effect of analgesic use on the risk of recurrent falls (≥2) in the following year, adjusted for demographics and health status/behavior factors.
resultsOpioid use increased from 2.7% at baseline to 3.6% at the 36-month visit (>80% using other analgesics/nutraceuticals), while other prescription pain medication use decreased from 16.7% to 11.9% over this time period. Approximately 15% of participants reported recurrent falls. Compared to those not using analgesics, participants who used opioids and/or antidepressants had a 22-25% increased risk of recurrent falls (opioids: RR
conclusionParticipants with or at risk of knee OA who used opioids and antidepressants with/without other analgesics/nutraceuticals may have an increased risk of recurrent falls after adjusting for potential confounders. Use of opioids and antidepressants warrants caution.
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