Trial reportJournal of the American College of Cardiology2017
Detection of Atherosclerotic Inflammation by
5 registry-linked trialsOpen access · hybridAbstract readClinical TrialComparative Study
In one paragraph
Trial report in Journal of the American College of Cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 236 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
236citing papers in PubMed, 5 pooled it
29.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PET Imaging of Inflammation and Lipid Lowering Study
PMID 25977567other papers from this trial
Open the trial in the graphThe PET Imaging of Giant Cell and Takayasu Arteritis Study
Residual Inflammation and Plaque Progression Long-term Evaluation
Synergy Between morpHOlogical and inflammatoRy Evaluation in Predicting Long-term Coronary Plaque Progression
Molecular Imaging in Fabry Disease of the Heart
Who cites it
236 citing papers in PubMed, 5 syntheses or guidelines pooled it, 417 citations in OpenAlex.
- Discussion on the comparison of Raman spectroscopy and cardiovascular disease-related imaging techniques and the future applications of Raman technology: a systematic review.Lasers in medical science · 2025Pooled it
- Diagnostic test accuracies of F-18 FDG PET for characterisation of cardiac masses compared to conventional imaging techniques: systematic review and meta-analysis.The British journal of radiology · 2022Pooled it
- Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last Decade.International journal of molecular sciences · 2022Pooled it
- Overview of the RGD-Based PET Agents Use in Patients With Cardiovascular Diseases: A Systematic Review.Frontiers in medicine · 2022Pooled it
- Somatostatin receptor imaging by SPECT and PET in patients with chronic inflammatory disorders: a systematic review.European journal of nuclear medicine and molecular imaging · 2019Pooled it
- Effect of 26 Weeks of Liraglutide Treatment on Coronary Artery Inflammation in Type 2 Diabetes Quantified by [Frontiers in endocrinology · 2021Trial
- Simultaneous DOTATATE uptake in three non-neuroendocrine pathologies: Follicular lymphoma, Crohn's disease, and vertebral hemangioma.Radiology case reports · 2026Article
- Functional pituitary adenoma imaging.Reviews in endocrine & metabolic disorders · 2026Review
- Molecular imaging of atherosclerotic plaque vulnerability: a narrative review.The international journal of cardiovascular imaging · 2026Review
- Coronary artery disease imaging with total-body PET.The British journal of radiology · 2026Review
- Cardiovascular imaging with total-body PET.The British journal of radiology · 2026Review
- Mitochondrial Redox Failure Links Senescence-like Foam Cell Stress to Ferroptosis and Plaque Non-Resolution in Atherosclerosis.Antioxidants (Basel, Switzerland) · 2026Review
- The Statin Floor Effect: a Mechanistic Framework for Residual Cardiovascular Risk.Cardiovascular drugs and therapy · 2026Review
- Carotid plaque inflammation and calcification on somatostatin receptor PET/CT imaging predict stroke and major adverse cardiovascular events.European heart journal. Cardiovascular Imaging · 2026Article
- Vein graft failure: Pathophysiology, detection, prevention and emerging therapeutic strategies.Pharmacological reviews · 2026Review
- In Vivo Imaging of the Innate Immune System in the Pancreas in New-Onset and Long-Standing Type 1 Diabetes.Diabetes, obesity & metabolism · 2026Article
- Magnetic Particle Imaging for Pulmonary Applications: Technological Advances, Biological Insights, and Clinical Translation.Bioengineering (Basel, Switzerland) · 2026Review
- Pericoronary adipose tissue as a biomarker of coronary atherosclerosis and cardiovascular risk in rheumatoid arthritis.Rheumatology (Oxford, England) · 2026Observational
- Assessment of carotid atherosclerotic plaque vulnerability with multi-radiotracer PET/CT: a scoping review.European radiology · 2026Article
- Article
176 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
26 authors at 5 institutions in 2 countries.
Jason M TarkinDivision of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom.
Francis R JoshiHeart Center, Rigshospitalet, Copenhagen, Denmark.
Nicholas R EvansDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Mohammed M ChowdhuryDepartment of Vascular and Endovascular Surgery, Addenbrooke's Hospital, Cambridge, United Kingdom.
Nichola L FiggDivision of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom.
Aarti V ShahDivision of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom.
Lakshi T StarksDivision of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom.
Abel Martin-GarridoDivision of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom.
Roido ManavakiDepartment of Radiology, University of Cambridge, Cambridge, United Kingdom.
Emma YuDivision of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom.
Rhoda E KucExperimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, United Kingdom.
Luigi GrassiDepartment of Hematology, University of Cambridge, and National Health Service Blood and Transport, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Roman KreuzhuberDepartment of Hematology, University of Cambridge, and National Health Service Blood and Transport, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Myrto A KostadimaDepartment of Hematology, University of Cambridge, and National Health Service Blood and Transport, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Mattia FrontiniDepartment of Hematology, University of Cambridge, and National Health Service Blood and Transport, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Peter J KirkpatrickDivision of Neurosurgery, Addenbrooke's Hospital, Cambridge, United Kingdom.
Patrick A CoughlinDepartment of Vascular and Endovascular Surgery, Addenbrooke's Hospital, Cambridge, United Kingdom.
Deepa GopalanDepartment of Radiology, University of Cambridge, Cambridge, United Kingdom; Department of Radiology, Hammersmith Hospital, London, United Kingdom.
Tim D FryerDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
John R BuscombeDepartment of Nuclear Medicine, Addenbrooke's Hospital, Cambridge, United Kingdom.
Ashley M GrovesInstitute of Nuclear Medicine, University College London, London, United Kingdom.
Willem H OuwehandDepartment of Hematology, University of Cambridge, and National Health Service Blood and Transport, Cambridge Biomedical Campus, Cambridge, United Kingdom; Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom.
Martin R BennettDivision of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom.
Elizabeth A WarburtonDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Anthony P DavenportExperimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, United Kingdom.
James H F RuddDivision of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom. Electronic address: jhfr2@cam.ac.uk.
University of Cambridge · GBAddenbrooke's Hospital · GBNational Health Service · GBRigshospitalet · DKUniversity College London · GB
Funding
REGULATION OF FIBRONECTIN IN CARDIAC FIBROBLASTSF32HL009083 · NHLBI · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI KIM, NOEL N · 1994 to 1995
–FOAM COUNTERCURRENT CHROMATOGRAPHY WITH A COIL PLANET CENTRIFUGEZ01HL001469 · NHLBI · HEART, LUNG, AND BLOOD INSTITUTE · PI ITO, Y · 1989 to 1989
–British Heart Foundation FS/12/29/29463British Heart Foundation PG/09/083/27667British Heart Foundation PG/14/69/31032British Heart Foundation RG/13/14/30314Medical Research Council MC_PC_14116The Dunhill Medical Trust RTF44/0114
Abstract
backgroundInflammation drives atherosclerotic plaque rupture. Although inflammation can be measured using fluorine-18-labeled fluorodeoxyglucose positron emission tomography ([
objectivesThis study tested the efficacy of gallium-68-labeled DOTATATE (
methodsWe confirmed
resultsTarget SSTR2 gene expression occurred exclusively in "proinflammatory" M1 macrophages, specific
conclusionsWe validated
Indexed as
Fluorodeoxyglucose F18Organometallic CompoundsPositron Emission Tomography Computed TomographyAgedAtherosclerosisCarotid ArteriesCoronary VesselsFemaleHumansInflammationMacrophagesMaleMiddle AgedReceptors, SomatostatinFluorodeoxyglucose F18gallium Ga 68 dotatateOrganometallic CompoundsReceptors, SomatostatinSSTR2 protein, humanatherosclerosisinflammationmacrophagesmolecular imagingpositron emission tomographysomatostatin receptor
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
NCT04073797ClinicalTrials.gov
NCT04071691ClinicalTrials.gov
NCT04073810ClinicalTrials.gov
NCT05436977ClinicalTrials.gov
NCT06226987ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.