ArticleBMC biology2017
OsLG3 contributing to rice grain length and yield was mined by Ho-LAMap.
Article in BMC biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
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72 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-QTLs, ortho-meta-QTLs and candidate genes for grain yield and associated traits in wheat (Triticum aestivum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Pooled it
- Article
- FAD-Linked Oxidoreductase Protein 1 (FLO1) Coordinates Grain Development and Drought Tolerance in Rice.Plants (Basel, Switzerland) · 2026Article
- Integrative machine learning approach for identifying genes associated with quantitative traits: A soybean (Glycine max) yield case study.The plant genome · 2026Article
- Identification of QTLs and genes regulating panicle number through genome-wide association studies inFrontiers in plant science · 2026Article
- The LARGE1 controls grain size by repressing the interaction between PGL2 and APG in rice.The Plant journal : for cell and molecular biology · 2026Article
- Fine Mapping and Candidate Gene Identification of ORUFILM03g000096 Gene in Weedy Rice LM8: Insights into Grain Length Regulation.Rice (New York, N.Y.) · 2025Article
- Grain shape in rice: a Genome-wide association study of the effector genes.BMC plant biology · 2025Article
- Research Advances in AP2/ERF Transcription Factors in Rice Growth and Development.Plants (Basel, Switzerland) · 2025Review
- Identification of an adaptor protein 2σ gene for OsTGW12 to determine grain weight and potentiate quality breeding in rice.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- A Novel OsMPK6-OsMADS47-PPKL1/3 Module Controls Grain Shape and Yield in Rice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Harnessing neo-domestication of wild pigmented rice for enhanced nutrition and sustainable agriculture.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Genetic Improvement of rice Grain size Using the CRISPR/Cas9 System.Rice (New York, N.Y.) · 2025Review
- Linkage Mapping and Identification of Candidate Genes for Cold Tolerance in Rice (Oryza Sativa L.) at the Bud Bursting Stage.Rice (New York, N.Y.) · 2025Article
- Dissection and Fine-Mapping of Two QTL Controlling Grain Size Linked in a 515.6-kb Region on Chromosome 10 of Rice.Plants (Basel, Switzerland) · 2024Article
- OsMAPK6 phosphorylation and CLG1 ubiquitylation of GW6a non-additively enhance rice grain size through stabilization of the substrate.Nature communications · 2024Article
- Article
- Article
- Dissecting the Genetic Basis of Yield Traits and Validation of a Novel Quantitative Trait Locus for Grain Width and Weight in Rice.Plants (Basel, Switzerland) · 2024Article
- Genome-Wide Identification and Expression Analysis of theInternational journal of molecular sciences · 2024Article
12 more citing papers are in PubMed but not listed here.
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20 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMost agronomic traits in rice are complex and polygenic. The identification of quantitative trait loci (QTL) for grain length is an important objective of rice genetic research and breeding programs.
resultsHerein, we identified 99 QTL for grain length by GWAS based on approximately 10 million single nucleotide polymorphisms from 504 cultivated rice accessions (Oryza sativa L.), 13 of which were validated by four linkage populations and 92 were new loci for grain length. We scanned the Ho (observed heterozygosity per locus) index of coupled-parents of crosses mapping the same QTL, based on linkage and association mapping, and identified two new genes for grain length. We named this approach as Ho-LAMap. A simulation study of six known genes showed that Ho-LAMap could mine genes rapidly across a wide range of experimental variables using deep-sequencing data. We used Ho-LAMap to clone a new gene, OsLG3, as a positive regulator of grain length, which could improve rice yield without influencing grain quality. Sequencing of the promoter region in 283 rice accessions from a wide geographic range identified four haplotypes that seem to be associated with grain length. Further analysis showed that OsLG3 alleles in the indica and japonica evolved independently from distinct ancestors and low nucleotide diversity of OsLG3 in indica indicated artificial selection. Phylogenetic analysis showed that OsLG3 might have much potential value for improvement of grain length in japonica breeding.
conclusionsThe results demonstrated that Ho-LAMap is a potential approach for gene discovery and OsLG3 is a promising gene to be utilized in genomic assisted breeding for rice cultivar improvement.
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