Evidence map›Paper›PMID 28385153›Full record

ArticleBMC nephrology2017

Lower serum magnesium is associated with vascular calcification in peritoneal dialysis patients: a cross sectional study.

Amber O Molnar, Mohan Biyani, Ian Hammond, John Paul Harmon, Susan Lavoie, Brendan McCormick, Manish M Sood, Jessica Wagner, Elena Pena, Deborah L Zimmerman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 54 citations in OpenAlex.

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  13. Magnesium to prevent kidney disease-associated vascular calcification: crystal clear?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Amber O MolnarDivision of Nephrology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Mohan BiyaniDivision of Nephrology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Ian HammondDepartment of Radiology, University of Ottawa, Ottawa, ON, Canada.
John Paul HarmonDivision of Nephrology, Department of Medicine, Northern Ontario School of Medicine, Sudbury, ON, Canada.
Susan LavoieDivision of Nephrology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Brendan McCormickDivision of Nephrology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Manish M SoodDivision of Nephrology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Jessica WagnerDivision of Nephrology, Department of Medicine, Northern Ontario School of Medicine, Sudbury, ON, Canada.
Elena PenaDepartment of Radiology, University of Ottawa, Ottawa, ON, Canada.
Deborah L ZimmermanDivision of Nephrology, Department of Medicine, McMaster University, Hamilton, ON, Canada. dzimmerman@toh.on.ca.
McMaster University · CAOttawa Hospital · CANOSM University · CAOttawa Hospital Research Institute

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronary artery calcification (CAC) is highly prevalent among dialysis patients and is associated with increased cardiovascular and all cause mortality. Magnesium (Mg) inhibits vascular calcification in animal and in-vitro studies but whether the same effect occurs in humans is uncertain.

methodsA single centre cross-sectional study of 80 prevalent peritoneal dialysis (PD) patients; on PD only for a minimum of 3 months. A radiologist blinded to patient status calculated their abdominal aortic calcification (AAC) scores on lateral lumbar spine radiographs, a validated surrogate for CAC.

resultsEighty patients provided informed consent and underwent lumbar spine radiography. The mean serum Mg was 0.8 mmol/L (standard deviation 0.2) and mean AAC score 8.9 (minimum 0, maximum 24). A higher serum Mg level was associated with a lower AAC score (R

conclusionsOur findings suggest that Mg may inhibit vascular calcification. If this association is replicated across larger studies with serial Mg and vascular calcification measurements, interventions that increase serum Mg and their effect on vascular calcification warrant further investigation in the PD population.

Indexed as

Peritoneal DialysisAgedAorta, AbdominalAortic DiseasesCholesterol, LDLCross-Sectional StudiesFemaleHumansKidney Failure, ChronicMagnesiumMaleMiddle AgedOntarioParathyroid HormoneRadiographyRisk FactorsCholesterol, LDLMagnesiumParathyroid HormoneMagnesiumPeritoneal dialysisVascular calcification

Identifiers

PMID28385153
PMCPMC5382660
OpenAlexW2604820856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.