ArticlePharmaceutical biology2017
Phytochemical composition, anti-inflammatory activity and cytotoxic effects of essential oils from three Pinus spp.
Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Delta-3-Carene Presented Anti-Inflammatory and Antinociceptive Properties by Modulating Leukocyte Activation in the Experimental Inflammatory Response In Vitro and In Vivo.Molecules (Basel, Switzerland) · 2026Article
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- Comparative anti-cancer properties of carene isoforms induced apoptotic cell death in stomach and lung cancer cell lines.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Liposomal Encapsulation of Pine Green Cone Essential Oil: The Influence of the Carrier on the Enhancement of Anti-Inflammatory Activity.Pharmaceutics · 2025Article
- Antimicrobial and Antioxidant Activity of Essential Oils from SelectedAntibiotics (Basel, Switzerland) · 2025Review
- Ethnopharmacology ofFrontiers in pharmacology · 2025Review
- Phytochemical Composition ofCurrent pharmaceutical biotechnology · 2025Article
- Comparative Study of Essential Oils from TunisianACS omega · 2024Article
- Antitumor activity of α-pinene in T-cell tumors.Cancer science · 2024Article
- Antioxidant Activity of Essential Oils from Pinaceae Species.Antioxidants (Basel, Switzerland) · 2024Review
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- Chemometric analysis of monoterpenes and sesquiterpenes of conifers.Frontiers in plant science · 2024Article
- Terpenoids as principal bioactive compound ofFrontiers in cellular and infection microbiology · 2024Article
- Phytochemical Composition, Antioxidant and Antiproliferative Activities ofPlants (Basel, Switzerland) · 2022Article
- The attenuation effect of low piperinePharmaceutical biology · 2022Article
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- Characterization and In Vivo Anti-Inflammatory Efficacy of Copal (Plants (Basel, Switzerland) · 2022Article
- Traditional processing increases biological activities of Dendrobium offificinale Kimura et. Migo in Southeast Yunnan, China.Scientific reports · 2022Article
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- Synthesis, antifungal activity and 3D-QSAR study of novel acyl thiourea compounds containing gem-dimethylcyclopropane ring.Molecular diversity · 2022Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextInflammation and cell differentiation lead to a number of severe diseases. In the recent years, various studies focused on the anti-inflammatory and anticancer activity of essential oils (EOs) of numerous plants, including different Pinus species.
objectiveThe phytochemical composition, anti-inflammatory and cytotoxic activity of EOs from needles and twigs of Pinus heldreichii Christ (Pinaceae) and P. peuce Griseb., and from needles, twigs and cones of P. mugo Turra were determined. MATERIALS AND
methodsFor separation and identification of the EOs, gas chromatography/flame ion detector (GC/FID) and GC/mass spectrometry were performed. The amount of secreted IL-6 in a lipopolysaccharide (LPS)-stimulated macrophage model was quantified (concentration of oils: 0.0001-0.2%, 3 h incubation). Cytotoxicity on the cancer cell lines HeLa, CaCo-2 and MCF-7 were determined using a MTT (Thiazolyl Blue Tetrazolium Bromide) assay (concentration of oils: 0.001-0.1%, 24 h incubation).
resultsThe most prominent members in the oils include: δ-3-carene, α-pinene and linalool-acetate (P. mugo); α-pinene, β-phellandrene and β-pinene (P. peuce); limonene, α-pinene and (E)-caryophyllene (P. heldreichii). EOs showed significant cytotoxic effects on cancer cell lines (IC DISCUSSION AND
conclusionThe EOs of needles and twigs from P. peuce and P. heldreichii as well as of needles, twigs and cones of P. mugo can be considered as promising agents for anticancer and anti-inflammatory drugs.
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