Evidence map›Paper›PMID 28384870›Full record

ArticleJournal of clinical and diagnostic research : JCDR2017

Significant Haematogone Proliferation Mimicking Relapse in Acute Lymphoblastic Leukaemia on Therapy.

Smeeta Gajendra, Ruchira Misra, Pranav Dorwal, Rashi Sharma, Ritesh Sachdev

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and diagnostic research : JCDR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Analytical Appraisal of Hematogones in B-ALL MRD Assessment Using Multidimensional Dot-Plots by Multiparametric Flow Cytometry: A Critical Review and Update.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Smeeta GajendraAssociate Consultant, Department of Pathology and Laboratory Medicine, Medanta - The Medicity , Gurgaon, Haryana, India .
Ruchira MisraConsultant, Department of Paediatric Hemat-Oncology, Medanta - The Medicity , Gurgaon, Haryana, India .
Pranav DorwalAssociate Consultant, Department of Pathology and Laboratory Medicine, Medanta - The Medicity , Gurgaon, Haryana, India .
Rashi SharmaSenior Resident, Department of Pathology and Laboratory Medicine, Medanta - The Medicity , Gurgaon, Haryana, India .
Ritesh SachdevSenior Consultant, Department of Pathology and Laboratory Medicine, Medanta - The Medicity , Gurgaon, Haryana, India .

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Haematogones are benign B lymphoid precursors which may mimic neoplastic lymphoblasts and pose diagnostic difficulty especially when the percentage of haematogones exceeds 10% in the bone marrow. Flow cytometric analysis with combination of CD19/CD10/CD20/CD34/CD38/CD58 can be used to differentiate the two depending upon the difference in the fluorescence intensity between blasts and haematogones. We hereby present a case of Common Acute Lymphoblastic Leukaemia Associated Antigen (CALLA) positive Acute Lymphoblastic Leukaemia (ALL), in which patient presented with haematogone proliferation in bone marrow after 6 months of chemotherapy mimicking relapse. The distinction was made on flow cytometric immunophenotyping by using optimal antibody combination. Distinction of benign haematogones from neoplastic lymphoblasts is essential for disease management in cases of post chemotherapy or post marrow transplant, especially in patients of ALL. Flow cytometric immunophenotyping is reliable to distinguish haematogones from residual lymphoblasts in almost all cases when optimal antibody combinations are used.

Indexed as

Benign B lymphoid precursorsFlow cytometryMinimal Residual Disease

Identifiers

PMID28384870
PMCPMC5376839

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