Evidence map›Paper›PMID 28384852›Full record

ArticleJournal of clinical and diagnostic research : JCDR2017

Association of +62 G>A Polymorphism in the Resistin Gene with Type 2 Diabetes Mellitus among Thais: Case-Control Study.

Theerawut Thammakun, Wongsa Laohasiriwong, Ratthaphol Kraiklang, Nittaya Saengprajak

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and diagnostic research : JCDR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Theerawut ThammakunFaculty, Department of Public Health, Khon Kaen University and Research and Training Center for Enhancing Quality of Life of Working Age People, Khon Kaen University , Khon Kaen, Thailand .
Wongsa LaohasiriwongAssociate Professor, Department of Public Health, Khon Kaen University and Board Committee of Research and Training Centre for Enhancing Quality of Life of Working Age People (REQW), Khon Kaen University , Khon Kaen, Thailand .
Ratthaphol KraiklangLecturer, Department of Public Health, Khon Kaen University and Research Group on Prevention and Control of Diabetes in the Northeast , Khon Kaen, Thailand .
Nittaya SaengprajakLecturer, Department of Public Health, Kalasin University , Kalasin, Thailand .
Khon Kaen University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionResistin gene (RETN) polymorphisms in humans may have a role in the pathogenesis of Type 2 Diabetes Mellitus (T2DM) and insulin resistance. There is still lack of evidence on association between +62 G>A polymorphism in the RETN and T2DM among Thais.

aimTo determine the effect of polymorphisms at +62 G>A of RETN on Thai T2DM. MATERIALS AND

methodsThis matched case control study was conducted with a total of 360 samples from all regions of Thailand (180 Thai new T2DM cases and 180 non-T2DM Thais for control) were enrolled. The RETN +62G>A polymorphism were detected using the Polymerase Chain Reaction (PCR) method. Conditional logistic regression was performed to test the association between +62 G>A polymorphism and T2DM.

resultsAmong 360 samples that were enrolled, only 350 samples completed molecular analysis. It was found that GA+AA genotype frequencies in T2DM cases was higher than control by 16% (95% CI: 6.0%, 27.0%, p-value=0.002). After adjustments for possible confounders, multivariable analyses by conditional logistic regression showed that the RETN+62 G>A polymorphism was statistically associated with Thai T2DM (OR

conclusionThese findings suggest that RETN polymorphism at position +62 G>A may increase the susceptibility to T2DM in Thais.

Indexed as

Metabolic syndromeMolecular analysisRisk factorsThailand

Identifiers

PMID28384852
PMCPMC5376897
OpenAlexW2590003813

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.