Evidence map›Paper›PMID 28384803›Full record

ArticleJournal of speech, language, and hearing research : JSLHR2017

A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: II. Validity Studies of the Pause Marker.

Lawrence D Shriberg, Edythe A Strand, Marios Fourakis, Kathy J Jakielski, Sheryl D Hall, Heather B Karlsson, Heather L Mabie, Jane L McSweeny, Christie M Tilkens, David L Wilson

Abstract readValidation Study
In one paragraph

Article in Journal of speech, language, and hearing research : JSLHR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Differential Diagnosis of Apraxia of Speech in Children and Adults: A Scoping Review.Journal of speech, language, and hearing research : JSLHR · 2020
    Article
  8. Article
  9. Protocol for the Connected Speech Transcription of Children with Speech Disorders: An Example from Childhood Apraxia of Speech.Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) · 2020
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lawrence D ShribergWaisman Center, University of Wisconsin-Madison.
Edythe A StrandDepartment of Neurology, Mayo Clinic, Rochester, MN.
Marios FourakisWaisman Center, University of Wisconsin-Madison.
Kathy J JakielskiDepartment of Communication Sciences and Disorders, Augustana College, Rock Island, IL.
Sheryl D HallWaisman Center, University of Wisconsin-Madison.
Heather B KarlssonWaisman Center, University of Wisconsin-Madison.
Heather L MabieWaisman Center, University of Wisconsin-Madison.
Jane L McSweenyWaisman Center, University of Wisconsin-Madison.
Christie M TilkensWaisman Center, University of Wisconsin-Madison.
David L WilsonWaisman Center, University of Wisconsin-Madison.
University of Wisconsin–Madison · USAugustana College · USMayo Clinic in Arizona · US

Funding

WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J · 1985 to 2015
$25.2M
STUDIES IN DEVELOPMENTAL PHONOLOGICAL DISORDERSR01DC000496 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI SHRIBERG, LAWRENCE D · 1988 to 2017
$9.9M
NICHD NIH HHS P30 HD003352NIDCD NIH HHS R01 DC000496
6 · The paper itself

Abstract

Purpose: The purpose of this 2nd article in this supplement is to report validity support findings for the Pause Marker (PM), a proposed single-sign diagnostic marker of childhood apraxia of speech (CAS). Method: PM scores and additional perceptual and acoustic measures were obtained from 296 participants in cohorts with idiopathic and neurogenetic CAS, adult-onset apraxia of speech and primary progressive apraxia of speech, and idiopathic speech delay. Results: Adjusted for questionable specificity disagreements with a pediatric Mayo Clinic diagnostic standard, the estimated sensitivity and specificity, respectively, of the PM were 86.8% and 100% for the CAS cohort, yielding positive and negative likelihood ratios of 56.45 (95% confidence interval [CI]: [1.15, 2763.31]) and 0.13 (95% CI [0.06, 0.30]). Specificity of the PM for 4 cohorts totaling 205 participants with speech delay was 98.5%. Conclusion: These findings are interpreted as providing support for the PM as a near-conclusive diagnostic marker of CAS.

Indexed as

AdolescentAgedAged, 80 and overAge of OnsetApraxiasChildChild, PreschoolCohort StudiesDiagnosis, DifferentialFemaleHumansLanguage Development DisordersLanguage TestsMaleMiddle AgedSensitivity and Specificity

Identifiers

PMID28384803
PMCPMC5548087
OpenAlexW2604403276

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.